PEPTIDE MODULATION OF AFFILIATIVE AND ASOCIAL BEHAVIOR

亲和和社交行为的肽调节

• 批准号: 6477126
• 负责人: JAMES L GOODSON
• 金额: $ 18.62万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-12-15 至 2005-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477126
• 关键词: aggression; analog; animal communication behavior; behavior test; behavioral /social science research tag; binding sites; drug administration rate /duration; ethology; gender difference; immunocytochemistry; neuroanatomy; neuropeptides; neuropharmacology; oxytocin; psychobiology; psychopharmacology; sex behavior; social behavior; social cooperation; songbirds; species difference; territoriality; vasopressins

Neuropeptides of the vasopressin-oxytocin family play important roles in both affiliative and asocial behaviors across a broad range of vertebrate taxa. Similarly, recent findings in human clinical populations (personality disorder, autism, depression) indicate that impairments of sociality may be produced at least in part by dysfunctions of these peptide systems. The relevance of comparative data for human populations is further underscored by the observation that across vertebrate groups, including humans, behavioral functions and major features of vasopressin-oxytocin brain distributions are conserved. Nonetheless, vasopressin-oxytocin systems exhibit remarkably plastic features as well. A variety of data now suggest the hypothesis advanced here that the expression of specific and integrated patterns of behavior (e.g., behavior typical or specific to an individual's sex, social tactics, and species' social structure) is produced in part by the functional lability of vasopressin-oxytocin systems. However, few experiments have explicitly tested for sex differences in the modulation of similar behaviors, and in most species, only a limited range of social behaviors have been examined. Proposed experiments will employ intracerebroventricular infusions of vasopressin- and oxytocin-like peptides in both male and female songbirds to determine neuropeptide functions for a broad , range of behaviors, including aggression, courtship, sexual behavior, partner preference (typical of monogamous pair-bonds), and non-sexual affiliation. The diversity of social structures in songbirds allows specific aspects of behavior to be examined while holding potential confounds constant; our previous experiments have shown that neuropeptides modulate male aggression differently in colonial vs. territorial songbird species (i.e., highly gregarious vs. relatively asocial). Experiments proposed here extend these species comparisons to females and to a broader range of social behaviors. Finally, neuroanatomical techniques (immunocytochemistry for immediate early gene expression and peptides; quantitative autoradiography) will be used to establish neural bases for the previously-identified divergence in peptide function between affiliative and asocial species.

加压素 - 氧气毒素家族的神经肽在跨脊椎动物类群中都起着重要作用。同样，人类临床人群（人格障碍，自闭症，抑郁症）的最新发现表明，社会性障碍至少部分是由于这些肽系统的功能障碍而产生的。 比较数据对人类种群的相关性进一步强调了以下观察结果，即在包括人类，行为功能以及加压素 - 氧气蛋白质脑分布的主要特征（包括人类，行为功能和主要特征）中。 尽管如此，加压素 - 氧气蛋白系统也表现出非常明显的塑性特征。 现在，各种数据都表明，这里提出的假设是，特定和综合行为模式的表达（例如，行为典型或特定于个人的性别，社会策略和物种的社会结构），部分是由功能不稳定产生的加压素 - 氧气系统。 但是，很少有实验对相似行为的调节中的性别差异进行了明确的测试，而且在大多数物种中，仅研究了有限的社会行为。 拟议的实验将采用男性和雌性鸣鸟中加压素和催产素样肽的脑室内脑室输注，以确定神经肽的功能，用于广泛的行为范围，包括侵略性，求爱，求爱，性行为，性行为，性行为，伴侣的偏好（典型的成对型物种））和非性隶属关系。 鸣禽中社会结构的多样性允许在保持潜在混淆的同时检查行为的特定方面。我们以前的实验表明，神经肽在殖民地与领土鸣鸟物种中对男性侵略的调节不同（即高度群体与相对不可抗化）。这里提出的实验将这些物种的比较扩展到女性和更广泛的社会行为。 最后，将使用神经解剖技术（立即进行早期基因表达和肽的免疫细胞化学化学；定量自显影术）来建立隶属关系和社会社会物种之间肽功能中先前识别的差异的神经碱基。