Quantification of Blood Volume Flow Using Ultrasound

使用超声波量化血流量

• 批准号: 6527770
• 负责人: JEFFREY B FOWLKES
• 金额: $ 25.55万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-20 至 2004-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527770
• 关键词: bioimaging /biomedical imaging; biomedical equipment development; blood volume; clinical research; diagnosis design /evaluation; dogs; human subject; mathematical model; phantom model; pulse pressure wave; ultrasound blood flow measurement

DESCRIPTION (Provided by Applicant): The goal of this proposal is to develop, analyze, and test an innovative technique for measuring volume blood flow ultrasonically. The quantification of volumetric flow is useful for a number of clinical applications including estimation of cardiac output, monitoring of cerebrovascular diseases, and evaluation of intrauterine growth restriction (IUGR) during pregnancy. Current techniques for measuring volumetric flow are either invasive (i.e. insertion of a Swan-Ganz catheter) or have limited accuracy (i.e. calculations based on Doppler measurements). The long term goal of this project is to defme a real-time, angle-independent volumetric flow measurement technique that can be implemented with current clinical scanner architecture. The proposed algorithm incorporates steered Doppler with the decorrelation of the raw ultrasound RF signals to compute the 3-D vector velocity profile of a vessel using a single transducer. Integration of the normal flow component over a cross-section of the vessel provides the total volume flow. This study will test implementation using modified pulsing sequences and digital correlators currently used in standard Doppler ultrasound machines. The algorithm will initially be verified on steady flow of blood-mimicking fluids in phantoms. A permutation test will be used to determine optimal parameter settings and ifitering schemes. Pulsatile waveforms and velocities in physiological ranges will be examined for accuracy and temporal resolution. Validation of the technique in vivo will be done by measuring flow in canine arteries and comparing with electromagnetic flow cuff results. Final evaluation of the technique will involve a pilot study quantifying flow in grafts of human subjects undergoing dialysis.

描述（由申请人提供）：该提案的目的是开发， 分析并测试一种用于测量体积血流的创新技术 超声波。体积流的定量对于许多 临床应用，包括估计心脏输出，监测 脑血管疾病和宫内生长限制的评估 （IUGR）怀孕期间。当前测量体积流量的技术是 侵入性（即插入天鹅导管）或有限 精度（即基于多普勒测量值的计算）。长期目标 这个项目的是为实时，无角度的体积流动 可以使用当前临床扫描仪实施的测量技术 建筑学。 所提出的算法将转导的多普勒与去相关 原始的超声RF信号计算A的3-D矢量速度曲线 使用单个换能器的容器。正常流量组件的整合 容器的横截面提供了总体积流。这项研究会 使用修改的脉冲序列和数字相关器测试实现 目前用于标准多普勒超声计算机。 该算法最初将在稳定的仿血流中得到验证 幻影中的流体。排列测试将用于确定最佳 参数设置和ifiter计划。脉冲波形和速度 将检查生理范围的准确性和时间分辨率。 体内技术的验证将通过测量犬的流量来完成 动脉和与电磁流袖结果进行比较。最终评估 该技术将涉及一项试验研究，以量化人类移植物中的流量 接受透析的受试者。