A NON-HUMAN PRIMATE MODEL OF NATURAL MENOPAUSE

自然更年期的非人类灵长类动物模型

• 批准号: 6540555
• 负责人: ERIKA K HONORE
• 金额: $ 7.09万
• 依托单位: TEXAS BIOMEDICAL RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-03-15 至 2006-03-14
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6540555
• 关键词: aging; baboons; biological models; blood chemistry; blood lipoprotein; bone density; cardiovascular system; female; gonadotropins; hormone regulation /control mechanism; hormone therapy; longitudinal animal study; menopause; menstrual cycle; model design /development; nonhuman therapy evaluation; radiography; reproductive system; skeletal system; steroid hormone; therapy compliance; ultrasound blood flow measurement

DESCRIPTION (Adapted from the applicant's abstract): The proposed training and research will be conducted at the SRPRC and the University of Texas Health Science Center at San Antonio. Dr. Erika Honore is seeking SERCA support to advance her development as an independent investigator in comparative medicine, with emphasis on models for women's health. Dr. Honore has completed a postdoctoral fellowship at Wake Forest University studying estrogens and atherosclerosis in macaques. As part of the current proposal, she will receive further training and guidance from investigators in genetics, cardiology and reproductive endocrinology. Studies will utilize a well characterized, pedigreed colony of more than 250 female baboons to establish a NHP model of naturally occurring perimenopause and menopause. Postmenopausal women are at increased risk for cardiovascular disease and osteoporosis, as well as other conditions. Hormone replacement therapy (HRT) effectively reduces the risk, but only a fraction of U.S. women receive HRT. Research into menopause and HRT has relied on surgically ovariectomized NHPs as models of menopause. This does not adequately reflect the condition in women, where ovarian function declines gradually over several years and the postmenopausal ovary continues to produce androgens. Pilot data from the SRPRC indicate that aging female baboons undergo a natural transition into menopause with hormonal and physiological changes similar to those seen in women. The specific aims of this proposal are: 1) to characterize the perimenopausal period; 2) to determine the hormonal profiles of pre-, peri- and postmenopausal females; 3) to longitudinally assess relevant physiological variables in these three cohorts. These aims will be achieved through menstrual cycle analysis, assays of annual blood samples for hormones and lipoproteins, ultrasound measurements of peripheral vascular reactivity, and radiographic measurements of bone density. Interventional studies of novel HRT regimens are proposed for years 4 and 5 with the goal of increasing national compliance with HRT by developing an acceptable alternative.

描述（改编自申请人的摘要）：拟议的培训 研究将在 SRPRC 和德克萨斯大学健康中心进行 圣安东尼奥科学中心。 Erika Honore 博士正在寻求 SERCA 支持 促进她作为比较领域独立研究者的发展 医学，重点是妇女健康模型。 奥诺雷博士有 在维克森林大学完成博士后研究 雌激素和猕猴的动脉粥样硬化。 作为当前提案的一部分， 她将接受遗传学研究人员的进一步培训和指导， 心脏病学和生殖内分泌学。 研究将利用井 超过 250 只雌性狒狒的纯种群体，建立了一个 自然发生的围绝经期和更年期的 NHP 模型。 绝经后女性患心血管疾病的风险增加 骨质疏松症以及其他疾病。 激素替代疗法（HRT） 有效降低了风险，但只有一小部分美国女性接受了激素替代疗法。 对更年期和 HRT 的研究依赖于手术切除卵巢的 NHP 作为更年期模型。 这并不能充分反映情况 女性的卵巢功能在几年内逐渐衰退， 绝经后卵巢继续产生雄激素。 试点数据来自 SRPRC 表明，衰老的雌性狒狒会自然过渡到 更年期的荷尔蒙和生理变化类似于 女性。 该提案的具体目标是：1）描述围绝经期的特征 时期; 2) 确定孕前、孕期和孕期的荷尔蒙分布 绝经后女性； 3）纵向评估相关生理 这三个队列中的变量。 这些目标将通过 月经周期分析、每年血液样本的激素分析和 脂蛋白、外周血管反应性的超声测量，以及 骨密度的放射线测量。 小说介入研究 建议在第 4 年和第 5 年采用 HRT 方案，目标是增加 通过开发可接受的替代方案，全国遵守 HRT。