UTERINE CONTRACTILITY AND CERVICAL RIPENING IN PREGNANCY

妊娠期子宫收缩和宫颈成熟

• 批准号: 6498822
• 负责人: Robert E Garfield
• 金额: $ 29.89万
• 依托单位: UNIVERSITY OF TEXAS MED BR GALVESTON
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-02-01 至 2004-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6498822
• 关键词: age at pregnancy; birth; cervix; clinical research; collagen; computer assisted patient care; diagnosis design /evaluation; diagnosis quality /standard; electromyography; gestational age; health services research tag; human pregnant subject; induced labor; longitudinal human study; muscle contraction; noninvasive diagnosis; optics; outcomes research; patient care management; patient monitoring device; pregnancy; premature labor; racial /ethnic difference; statistics /biometry; uterus; women's health

The problems associated with labor during pregnancy are among the most important health issues facing physicians. Understanding the role of the uterus and cervix in labor and developing methods to control their function is essential to solving problems relating to labor. At the moment, only crude, inaccurate and subjective methods are used to assess changes in the uterus and cervix that occur in preparation for or during labor. In the past several years, the applicant and his colleagues have developed noninvasive methods to quantitatively evaluate the uterus and cervix based respectively on recording of uterine electrical signals from the abdominal surface (uterine EMG) and measurement of light- induced cervical collagen fluorescence (LIF) with an optical device (Collascope). The methods are rapid and allow assessment of uterine contractility and cervical ripening. Preliminary studies in rats and humans indicate that uterine and cervical function can be successfully monitored during pregnancy using these approaches and that these techniques might be used in a variety of conditions associated with labor to better define management. This application is for funds to extend the initial studies. Four studies are proposed using abdominal EMB recordings and cervical LIF. A competent team of investigators and staff has been assembled to fulfill the needs and goals of this proposal. The specific hypotheses are that LIF and abdominal EMG recordings can be used to: 1) differentiate between true and false labor; 2) predict the onset of labor; 3) monitor patients during tocolysis or induction of labor. The specific aims are to use EMG activity and LIF to determine if they are helpful to: 1) assess patients in true versus false labor; 2) monitor antepartum patients longitudinally; 3) examine the effectiveness of tocolytics or induction. The potential benefits of the proposed instrumentation and methods include reducing the rate of preterm delivery, improving maternal and perinatal outcome, monitoring treatment, decreasing cesarean section rate and improving research methods to understand uterine and cervical function.

怀孕期间与劳动有关的问题是最重要的 医生面临的重要健康问题。 了解角色 子宫和子宫颈劳动和开发方法以控制其 功能对于解决与劳动有关的问题至关重要。 在 时刻，只使用粗略，不准确和主观方法来评估 在准备或期间准备的子宫和子宫颈的变化 劳动。 在过去的几年中，申请人和他的同事有 开发了无创方法来定量评估子宫和 子宫颈分别基于子宫电信号记录 从腹表面（子宫EMG）和光测量 用光学装置诱导宫颈胶原蛋白荧光（LIF） （Collascope）。 这些方法很快，可以评估子宫 收缩和宫颈成熟。大鼠的初步研究 人类表明子宫和宫颈功能可以成功 使用这些方法在怀孕期间进行监测，这些方法 技术可以在与之相关的各种条件下使用 劳动以更好地定义管理。 此申请是用于资金 扩展初始研究。 提出了四个研究的研究 EMB记录和宫颈Lif。 一个合格的调查员团队， 员工已经组装以满足这一需求和目标 提议。 特定的假设是LIF和腹部EMG 录音可用于：1）区分真实和错误 劳动; 2）预测劳动的发作； 3）监测患者 劳动分解或诱导。 具体目的是使用EMG 活动和LIF确定它们是否有帮助：1）评估患者 在真实的劳动中； 2）监测动力的患者 纵向3）检查溶剂剂或诱导的有效性。 拟议的仪器和方法的潜在好处 包括降低早产率，提高母亲和 围产期结局，监测治疗，减少剖宫产 比率和改进的研究方法以了解子宫和宫颈 功能。