Aluminum bioavailability from foods

食物中铝的生物利用度

基本信息

批准号：
6417774
负责人：
Robert Allen Yokel
金额：
$ 23.63万
依托单位：
UNIVERSITY OF KENTUCKY
依托单位国家：
美国
项目类别：
财政年份：
2002
资助国家：
美国
起止时间：
2002-02-08 至 2004-12-31
项目状态：
已结题

项目摘要

There is concern about brain aluminum accumulation over the life span that might contribute to Alzheimer's disease and related neurodegenerative disorders. The overall objective of the proposed research is to test the null hypothesis that the bioavailability of Al is comparable from foods and from drinking water. If the null hypothesis is accepted the concern about Al intake for typical Americans should focus on food and not drinking water. The specific aims are to produce food products containing 26Al in the normal chemical species for these foods and determine Al oral bioavailability from these selected representative foods, compared to Al oral bioavailability from drinking water. Foods to be produced are a baked good and a processed cheese, in which 26Al will be incorporated during food production, and spinach and tea, in which 26Al will be incorporated during their hydroponic production. Al bioavailability will be determined from the area under the serum 26Al concentration x time curve after bolus administration of the 26Al-containing food compared to the equivalent term obtained from serum 27Al concentration produced by continuous intravenous 27Al infusion throughout the study. 26Al will be analyzed by accelerator mass spectroscopy; 27Al by atomic absorption spectroscopy. It is hypothesized that oral Al bioavailability from food will be less than from water, due to Al binding to food components that inhibit its absorption. The results will resolve the controversy whether drinking water contributes a significant amount of the Al that is absorbed by the human. The results will suggest whether health-based standards to regulate Al in drinking water should be considered by regulatory agencies or whether reduction of absorbed Al in the human can be more effectively achieved by reducing Al in foods.

人们担心在整个生命周期内脑铝积累，这可能导致阿尔茨海默氏病和相关的神经退行性疾病。拟议的研究的总体目的是检验零假设，即Al的生物利用度与食物和饮用水相当。如果接受了无效的假设，那么对典型美国人的摄入量的担忧应专注于食物而不是喝水。与饮用水中的口服生物利用度相比，这些食品的特定目的是为这些食物生产含有26AL的食品，并确定这些所选代表性食品的口服生物利用度。要生产的食物是一种烘焙食品和一种加工的奶酪，其中将在食品生产过程中掺入26块，菠菜和茶将在其水培生产过程中掺入26AL。与在整个研究过程中从连续的静脉内27AL输注产生的血清27AL浓度相比，将26AL食品给药后的血清26AL浓度X时间曲线在血清26AL浓度X时间曲线下的区域确定。 26AL将通过加速器质谱分析； 27通过原子吸收光谱法。假设食物中的口服生物利用度比水少，因为与抑制其吸收的食物成分结合。结果将解决饮用水是否贡献大量被人类吸收的AL。结果将表明，是否应通过监管机构来考虑基于健康的标准，或者是否应考虑减少人类吸收的Al，从而通过减少食品中的Al来更有效地实现。