NEURAL BASIS OF SEXUALLY DIMORPHIC BRAIN FUNCTION

性别二态性脑功能的神经基础

• 批准号: 6503842
• 负责人: Geert J. De Vries
• 金额: $ 10.68万
• 依托单位: UNIVERSITY OF MASSACHUSETTS AMHERST
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-06-01 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6503842
• 关键词: amygdala; animal developmental psychology; arginine vasopressin; behavioral /social science research tag; brain mapping; central neural pathway /tract; developmental neurobiology; gender difference; hormone regulation /control mechanism; maternal behavior; messenger RNA; microdialysis; microinjections; parent offspring interaction; sex behavior; species difference; thalamus; vole

DESCRIPTION (adapted from applicant's abstract): This is a request for an Independent Scientist Award. This grant aims to add to our understanding of the neural basis of sexually dimorphic brain function by focusing on a sexually dimorphic system that has been implicated in parental and other sexually dimorphic behaviors and functions. The hypothesis driving this grant is that sex differences in the brain not only serve to generate sex differences in centrally regulated processes and behaviors, but also may enable males and females to show remarkably similar behaviors even though their physiological and hormonal conditions differ dramatically. It does this by studying the role of the sexually dimorphic vasopressin-immunoreactive projections of the bed nucleus of the stria terminalis and the medical amygdaloid nucleus in parental behavior. The strategy is to compare two species of voles: prairie voles (Microtus pennsylvanicus), a monogamous species in which both males and females provide parental care, and meadow voles (Microtus pennsylvanicus), a promiscuous species in which only females provide parental care. This strategy allows comparison of the AvP-ir projections not only between males and females but also between males that show different parental involvement. The research will entail psychopharmacological, hormonal and developmental manipulations, anatomical and cell biological analyses of reproduction-related changes, and behavioral observation. By virtue of its topic this study will contribute to understanding both sex differences in the brain and the neural basis of maternal as well as paternal behavior. The last contribution will be new to the field since virtually nothing is known about neural structures underlying paternal behavior. Research Career Development support is requested to free the PI form teaching and administrative duties. This will allow him to develop new anatomical, cellular, and molecular strategies to assess the contributions of the sexually dimorphic vasopressin projections to parental behavior.

描述（改编自申请人的摘要）：这是对 独立科学家奖。 这笔赠款旨在加深我们对 通过关注性别二态性大脑功能的神经基础 与父母和其他人有关的性二态系统 两性行为和功能的二态性。 驱动这一现象的假设 格兰特认为，大脑中的性别差异不仅有助于产生性别 集中监管的流程和行为存在差异，但也可能 使男性和女性表现出非常相似的行为，即使 他们的生理和荷尔蒙状况差异很大。 确实如此 通过研究性二态性的作用来实现这一点 纹状体床核的加压素免疫反应性投射 终末肌和医学杏仁核在父母行为中的作用。 这 策略是比较两种田鼠：草原田鼠（Microtus pennsylvanicus），一夫一妻制的物种，其中雄性和雌性 提供父母照顾，草地田鼠（Microtus pennsylvanicus）是一种 杂乱的物种，其中只有雌性提供亲代照顾。 这 该策略不仅可以在男性之间比较 AvP-ir 预测 和女性之间，也包括表现出不同父母参与程度的男性之间。 该研究将涉及精神药理学、激素和发育方面的研究 操作、解剖和细胞生物学分析 繁殖相关的变化和行为观察。 凭借其 这项研究将有助于理解性别差异 大脑以及母亲和父亲行为的神经基础。 最后的贡献对于该领域来说是新的，因为几乎没有什么 了解父亲行为背后的神经结构。 研究生涯 请求开发支持以免费 PI 形式教学和 行政职责。 这将使他能够开发新的解剖学， 评估细胞和分子策略的贡献 性二态性加压素对父母行为的预测。