Population Coding of Species-Specific Vocalizations

物种特定发声的群体编码

• 批准号: 6494509
• 负责人: Ross Kenneth Snider
• 金额: $ 7.08万
• 依托单位: MONTANA STATE UNIVERSITY - BOZEMAN
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6494509
• 关键词: Callithricidae; auditory cortex; auditory discrimination; auditory feedback; cell cell interaction; central neural pathway /tract; communication; electrophysiology; implant; microelectrodes; neurons; vocalization

DESCRIPTION (provided by applicant): The ability of the auditory cortex to identify and extract relevant communication sounds in an acoustic environment that contains other irrelevant sounds is known as auditory scene analysis. This ability is important for any robust communication system that operates in a realistic environment. The goal of this application is to examine a possible mechanism by which auditory scene analysis is performed. This possible mechanism is the synchronous activity of neurons, which may facilitate the separation of vocalizations from other sounds. A large body of evidence indicates that synchronous neuronal activity is a general feature of cortical and thalamic networks. The functional role of this activity is still largely unknown, however. These findings have led to the hypothesis that synchronous activity reflects the grouping of distributed neuronal activities into a common representation of integrated stimulus features. This hypothesis predicts that synchronous interactions should occur between neurons located in multiple cortical areas. The objective of the proposed research is to expand our under-standing of synchronization in the auditory cortex. To achieve this goal, we will investigate the occurrence, proper ties, and stimulus dependence of temporal correlations of neuronal activity occurring simultaneously within and between auditory areas A1, R, and AL of marmoset auditory cortex. Simultaneous recordings will be made from each of the three auditory cortical areas while the marmoset vocally interacts with its peers in an unconstrained manner. This will permit an assessment of inter-areal synchrony, its temporal dynamics, and stimulus conditions under which it is expressed. A multichannel wireless system will be built to enable the process of recording and analyzing the activity of distributed groups of neurons in unrestrained animals. This will provide a powerful tool that will be used to trace neural pathways that process species-specific vocalizations. This will allow data to be recorded as animals naturally interact with each other, which is not possible with restrained animals. An additional benefit of the system is that is will provide a method of studying higher cortical areas where the optimal stimuli are not known a priori.

描述（申请人提供）：听觉皮层的能力 在声学环境中识别和提取相关的沟通声音 其中包含其他无关的声音被称为听觉场景分析。这种能力对于任何强大的沟通系统都很重要 在现实的环境中运作。该应用的目的是 检查进行听觉场景分析的可能机制。这 可能的机制是神经元的同步活性，这可能有助于 发声与其他声音的分离。大量证据 表明同步神经元活性是皮质的一般特征 和丘脑网络。该活动的功能作用仍然很大 但是，未知。这些发现导致了同步的假设 活动反映了分布式神经元活动的分组 综合刺激特征的表示。该假设预测 位于多个的神经元之间应发生同步相互作用 皮质区域。拟议的研究的目的是扩大我们的不足 听觉皮层中的同步。为了实现这一目标，我们 将研究的发生，正确的关系和刺激依赖性 神经元活动的时间相关性同时发生在和 在听觉区域A1，R和Al之间，Marmoset听觉皮层。同时 录音将来自三个听觉皮层区域的每个区域，而 Marmoset以不受约束的方式与同龄人进行声音互动。这会 允许评估美属跨同步，其时间动态和 表达的刺激条件。多通道无线系统 将建立以实现记录和分析活动的过程 在不受约束的动物中分布的神经元组。这将提供一个 功能强大的工具将用于追踪特定物种特定物种的神经途径 发声。这将使数据自然记录为动物 彼此相互作用，这与约束动物不可能。一个 该系统的额外好处是，将提供一种研究的方法 最佳刺激的较高皮质区域尚不清楚。