TUMOR GROWTH ARREST MEDIATED BY TRANSCRIPTION REPRESSORS

转录抑制子介导的肿瘤生长抑制

• 批准号: 6514088
• 负责人: WEIMIN FAN
• 金额: $ 17.87万
• 依托单位: MEDICAL UNIVERSITY OF SOUTH CAROLINA
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-01 至 2005-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6514088
• 关键词: biological signal transduction; cell cycle; cell line; cell proliferation; gene induction /repression; genetic regulation; genetic regulatory element; genetic transcription; glucocorticoids; hormone regulation /control mechanism; mutant; neoplastic growth; protein purification; tissue /cell culture; tumor suppressor genes; yeast two hybrid system

项目成果

The possible correlation between activation of NF-kappaB/IkappaB pathway and the susceptibility of tumor cells to paclitaxel-induced apoptosis.

NF-kappaB/IkappaB 通路的激活与肿瘤细胞对紫杉醇诱导的细胞凋亡的敏感性之间可能存在相关性。

• 发表时间: 2002
• 期刊: Oncology research
• 影响因子: 3.1
• 作者: Huang,Yi;Fang,Yong;Dziadyk,JenniferM;Norris,JamesS;Fan,Weimin
• 通讯作者: Fan,Weimin

In vitro and in vivo characterizations of tetrandrine on the reversal of P-glycoprotein-mediated drug resistance to paclitaxel.

• 发表时间: 2005-05
• 期刊: Anticancer research
• 影响因子: 2
• 作者: Xueming Zhu;M. Sui;W. Fan

Reduced expression of p53 and p21WAF1/CIP1 sensitizes human breast cancer cells to paclitaxel and its combination with 5-fluorouracil.

p53 和 p21WAF1/CIP1 表达的减少使人乳腺癌细胞对紫杉醇及其与 5-氟尿嘧啶的组合敏感。

• 发表时间: 2002
• 期刊: Anticancer research.
• 作者: Johnson,KoreyR;Fan,Weimin
• 通讯作者: Fan,Weimin

Regulation of Vinca alkaloid-induced apoptosis by NF-kappaB/IkappaB pathway in human tumor cells.

• 发表时间: 2004-03
• 期刊: Molecular cancer therapeutics
• 影响因子: 5.7
• 作者: Yi Huang;Yong Fang;Jin-min Wu;J. Dziadyk;Xueming Zhu;M. Sui;W. Fan

Paclitaxel-induced apoptosis may occur without a prior G2/M-phase arrest.

• 发表时间: 2004
• 期刊: Anticancer research
• 影响因子: 2
• 作者: J. Dziadyk;M. Sui;Xueming Zhu;W. Fan