Level encoding in the AN and CN of hearing-impaired

听障者 AN 和 CN 中的电平编码

• 批准号: 6486953
• 负责人: Michael G Heinz
• 金额: $ 3.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-02-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6486953
• 关键词: acoustic nerve; audiometry; auditory nuclei; auditory pathways; auditory threshold; cats; developmental neurobiology; ear hair cell; electrical measurement; electrophysiology; hearing disorders; loudness; neural recruitment; neurophysiology; postdoctoral investigator; sensorineural hearing loss; sound frequency; sound perception; verbal behavior

DESCRIPTION (provided by applicant): The proposed neurophysiological experiments are motivated by two fundamental aspects of sound-level encoding that are strongly affected by cochlear damage and that currently provide significant challenges for the design of effective hearing aids. (1) Loudness recruitment represents the reduced dynamic range and abnormal loudness growth present in almost all hearing-impaired persons with cochlear damage. It is often assumed that loudness is related to the total neural activity evoked by a sound; however, the nature of this relation remains unclear in normal and impaired ears. One aim is to systematically characterize the growth of neural activity with increasing stimulus level in a population of auditory-nerve (AN) fibers for normal and hearing-impaired cats. Stimuli are based on typical psychophysical studies that measure loudness recruitment, and include tones, broadband noise, speech, and masked tones. (2) Robust spectral-shape encoding of complex acoustic stimuli is necessary for many basic auditory functions that underlie communication. A significant enhancement in the representation of speech has been reported in the transformation from the AN to the cochlear nucleus (CN) in normal-hearing animals. The second aim is to compare spectral-shape encoding in the CN of normal and hearing- impaired cats. Two methods will be used to evaluate the relative-level sensitivity for encoding spectral shape in the different cell types of the ventral CN. The data collected will improve the understanding of how cochlear damage affects the neural representation of sound, and will provide useful information for the design of new hearing-aid strategies to overcome loudness recruitment while maintaining and enhancing spectral representation.

描述（由申请人提供）：提出的神经生理实验 是由声音级编码的两个基本方面的动机 受人工耳蜗损害的强烈影响，目前提供重大的 设计有效助听器的挑战。 （1）响度招募 表示动态范围减少和响度异常的生长 几乎所有的听力受损的人都受到人工耳蜗的损害。经常假定 响度与声音引起的总体神经活动有关。 但是，这种关系的性质在正常和受损中尚不清楚 耳朵。一个目的是系统地表征神经活动的生长 随着听觉神经群（AN）纤维的刺激水平的增加 正常和听力受损的猫。刺激基于典型的心理物理 测量响度募集的研究，包括音调，宽带噪声， 语音和蒙面的音调。 （2）复杂声学的稳健光谱形状编码 刺激是许多基础的基本听觉功能所必需的 沟通。语音代表的显着增强 在从AN到耳蜗核（CN）的转化中报道了 正常的动物。第二个目的是比较编码的光谱形状 正常和听力受损的猫的中央情报局。两种方法将用于 评估对编码光谱形状的相对级别灵敏度 腹CN的不同细胞类型。收集的数据将改善 了解耳蜗损害如何影响声音的神经表示， 并将为设计新的助听器策略提供有用的信息 在维护和增强光谱的同时克服响度招募 表示。