Interdisciplinary Training in Auditory Neuroscience

听觉神经科学跨学科培训

• 批准号: 10438816
• 负责人: Michael G Heinz
• 金额: $ 23.52万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10438816
• 关键词: Auditory; Neurosciences; Training

PROJECT SUMMARY/ABSTRACT There is a national need to advance the understanding of hearing in both healthy patients and those with various causes of hearing loss. The objective of the proposed program is to train the next generation of faculty who could populate colleges of science, engineering, and health sciences, as well as to send graduates into in order to advance auditory neuroscience training, this new graduate program will leverage faculty expertise in basic hearing science and technology development, from three Purdue University colleges (Science, Engineering, and Health & Human Sciences) and 6 doctoral admissions programs. Two types of investigators are included in the training program: 10 hearing scientists with focused research programs related to auditory system neuroscience, and 7 technology innovators who are trained in other disciplines (electrical, computer and biomedical engineering, and chemistry). Collectively and collaboratively, the program will expand knowledge about mechanisms at the molecular, cellular and systems levels that underlie auditory information processing. This fundamental knowledge can then be applied to better understand the changes that lead to pathologies of the auditory system due to damage, disease, aging, and congenital disorders, as well as understanding how hearing evolved and influences behavior and natural selection. Technological approaches to these questions include, but are not limited to, fluorescent sensors to detect purinergic signaling in the intact nervous system, biological implants for neuromodulation, high-resolution four-dimension calcium imaging deep in the mammalian brain, optogenetics and robotics (automated patch-clamping) for brain circuit analysis, and industry prepared to work toward creative solutions for treating hearing loss. Specifically, This training program is unique in that it is specifically designed to serve students with undergraduate degrees in the disparate disciplines of life science, physical science or engineering, and merge them into a unified cohort focused on auditory neuroscience. Students will be selected for a 2-year term on the training grant, beginning at the start of their second year. The training curriculum includes 3 core courses (one each in neuroscience, the auditory periphery, and signal processing), several recommended courses (e.g., in neurosurgery or neuroscience), a weekly Hearing Science seminar series, and yearly attendance at extramural hearing-related courses and/or auditory neuroscience conferences. In addition to administrative support for the program, the Purdue Institute for Integrative Neuroscience will provide students with additional resources, such as supervised grant writing, hands-on training in animal behavior and human stem cells, annual neuroscience retreats, and access to in-house competitions for travel grants and pilot funding for collaborative projects. Further, this program builds on Purdue's extensive history in training graduate students in collaborative research (particularly in hearing science and technology development), and preparing these students for successful research careers in academia, industry and the clinic. multimodal brain imaging methods.

项目概要/摘要 全国需要增进对健康患者和患有听力障碍的患者的听力的了解 各种原因造成的听力损失。 拟议计划的目标是培训下一代教师 谁可以填充科学、工程和健康科学学院，以及将毕业生送入 为了推进 听觉神经科学培训，这个新的研究生课程将利用基础听力方面的教师专业知识 普渡大学三个学院（科学学院、工程学院和 健康与人类科学）和 6 个博士招生项目。调查中包括两类调查员 培训项目：10名听力科学家，从事与听觉系统相关的重点研究项目 神经科学，以及 7 名接受过其他学科（电气、计算机和 生物医学工程和化学）。该计划将通过集体和协作扩展知识 关于听觉信息处理的分子、细胞和系统水平的机制。 然后可以应用这些基础知识来更好地理解导致病理的变化 听觉系统因损伤、疾病、衰老和先天性疾病而受损，并了解如何 听觉的进化并影响行为和自然选择。解决这些问题的技术方法 包括但不限于检测完整神经系统中嘌呤能信号传导的荧光传感器， 用于神经调节的生物植入物，深层的高分辨率四维钙成像 用于脑回路分析的哺乳动物大脑、光遗传学和机器人技术（自动膜片钳），以及 业界准备致力于寻找治疗听力损失的创造性解决方案。具体来说， 该培训计划的独特之处在于它是专门为服务而设计的 拥有生命科学、物理科学或不同学科本科学位的学生 工程，并将它们合并成一个专注于听觉神经科学的统一队列。学生将被选拔 为期 2 年的培训补助金，从第二年年初开始。培训课程 包括 3 门核心课程（神经科学、听觉外围和信号处理各一门）， 推荐课程（例如神经外科或神经科学）、每周一次的听力科学研讨会系列，以及 每年参加校外听力相关课程和/或听觉神经科学会议。此外 为了对该计划的行政支持，普渡大学综合神经科学研究所将提供 学生拥有额外的资源，例如监督资助写作、动物行为的实践培训和 人类干细胞、年度神经科学静修以及参加内部竞赛以获得旅行补助和 合作项目试点资金。此外，该计划建立在普渡大学丰富的培训历史之上 合作研究（特别是听力科学和技术开发）的研究生，以及 为这些学生在学术界、工业界和临床上取得成功的研究生涯做好准备。 多模态脑成像方法。