Interdisciplinary Training in Auditory Neuroscience

听觉神经科学跨学科培训

• 批准号: 10438816
• 负责人: Michael G Heinz
• 金额: $ 23.52万
• 依托单位: PURDUE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2018
• 资助国家: 美国
• 起止时间: 2018-07-01 至 2023-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10438816
• 关键词: Auditory; Neurosciences; Training

PROJECT SUMMARY/ABSTRACT There is a national need to advance the understanding of hearing in both healthy patients and those with various causes of hearing loss. The objective of the proposed program is to train the next generation of faculty who could populate colleges of science, engineering, and health sciences, as well as to send graduates into in order to advance auditory neuroscience training, this new graduate program will leverage faculty expertise in basic hearing science and technology development, from three Purdue University colleges (Science, Engineering, and Health & Human Sciences) and 6 doctoral admissions programs. Two types of investigators are included in the training program: 10 hearing scientists with focused research programs related to auditory system neuroscience, and 7 technology innovators who are trained in other disciplines (electrical, computer and biomedical engineering, and chemistry). Collectively and collaboratively, the program will expand knowledge about mechanisms at the molecular, cellular and systems levels that underlie auditory information processing. This fundamental knowledge can then be applied to better understand the changes that lead to pathologies of the auditory system due to damage, disease, aging, and congenital disorders, as well as understanding how hearing evolved and influences behavior and natural selection. Technological approaches to these questions include, but are not limited to, fluorescent sensors to detect purinergic signaling in the intact nervous system, biological implants for neuromodulation, high-resolution four-dimension calcium imaging deep in the mammalian brain, optogenetics and robotics (automated patch-clamping) for brain circuit analysis, and industry prepared to work toward creative solutions for treating hearing loss. Specifically, This training program is unique in that it is specifically designed to serve students with undergraduate degrees in the disparate disciplines of life science, physical science or engineering, and merge them into a unified cohort focused on auditory neuroscience. Students will be selected for a 2-year term on the training grant, beginning at the start of their second year. The training curriculum includes 3 core courses (one each in neuroscience, the auditory periphery, and signal processing), several recommended courses (e.g., in neurosurgery or neuroscience), a weekly Hearing Science seminar series, and yearly attendance at extramural hearing-related courses and/or auditory neuroscience conferences. In addition to administrative support for the program, the Purdue Institute for Integrative Neuroscience will provide students with additional resources, such as supervised grant writing, hands-on training in animal behavior and human stem cells, annual neuroscience retreats, and access to in-house competitions for travel grants and pilot funding for collaborative projects. Further, this program builds on Purdue's extensive history in training graduate students in collaborative research (particularly in hearing science and technology development), and preparing these students for successful research careers in academia, industry and the clinic. multimodal brain imaging methods.

项目摘要/摘要 健康患者和患有患者的听力的理解是有国家的 听力损失的各种原因。 拟议计划的目的是培训下一代教师 谁可以填充科学，工程和健康科学学院，并将毕业生送入 为了进步 听觉神经科学培训，这项新的研究生课程将利用基本听证的教师专业知识 科学技术发展，来自三所普渡大学学院（科学，工程和 健康与人类科学）和6个博士入学计划。两种研究者包括 培训计划：10个与听觉系统有关的专注研究计划的听力科学家 神经科学和7个受过其他学科培训的技术创新者（电气，计算机和 生物医学工程和化学）。该计划集体和协作，扩展知识 关于基于听觉信息处理的分子，细胞和系统水平的机制。 然后可以应用这种基本知识，以更好地了解导致病理的变化 听觉系统由于损害，疾病，衰老和先天性疾病，并了解如何 听力进化并影响行为和自然选择。这些问题的技术方法 包括但不限于荧光传感器来检测完整神经系统中的嘌呤能信号传导， 用于神经调节的生物植入物，高分辨率四维钙成像深处 哺乳动物的大脑，光遗传学和机器人技术（自动贴片夹）用于脑电路分析，并且 行业准备致力于创造性解决方案，以治疗听力损失。具体来说， 该培训计划的独特之处在于它是专门设计的 在生活科学，物理科学或 工程，并将它们合并为一个专注于听觉神经科学的统一队列。学生将被选中 从第二年开始就获得了培训补助金的2年期。培训课程 包括3个核心课程（一个在神经科学，听觉外围和信号处理中），几个 推荐的课程（例如，在神经外科或神经科学中），每周的听力科学研讨会系列和 每年参加与听力外有关的课程和/或听觉神经科学会议。此外 为了对该计划的行政支持，普渡大学综合神经科学研究所将提供 具有其他资源的学生，例如受监督的赠款写作，动物行为的动手培训和 人类干细胞，每年的神经科学务虚会，并获得旅行补助的内部竞赛 合作项目的试点资金。此外，该计划以普渡大学在培训中的悠久历史为基础 合作研究的研究生（尤其是听力科学技术发展）， 为这些学生准备在学术界，工业和诊所的成功研究职业。 多模式脑成像方法。