Effects of Eye Position in the Auditory Pathway

眼睛位置对听觉通路的影响

• 批准号: 6552811
• 负责人: RYAN R METZGER
• 金额: $ 4.42万
• 依托单位: DARTMOUTH COLLEGE
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-05-01 至 2004-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6552811
• 关键词: Macaca mulatta; auditory cortex; auditory pathways; auditory stimulus; biological signal transduction; electrophysiology; eye movements; histochemistry /cytochemistry; inferior colliculus; magnetic resonance imaging; neural conduction; neurons; neurophysiology; operant conditionings; postdoctoral investigator; single cell analysis; sound frequency; sound perception; space perception

The locations of stimuli or events are initially encoded in separate frames of reference (eye-centered, head- (or ear-) centered, or body- centered). To coordinate and integrate the information gathered by the different sensory systems, the brain must translate the signals into a common frame of reference. This laboratory reported recently that eye position influences the auditory responses of some neurons in the inferior colliculus and auditory cortex, but that the frame of reference in these areas is intermediate between head- and eye-centered reference frames. Why does the brain process auditory space in such a fashion? Answering this question will lead to a better understanding of how the brain processes spatial information. Hence, the objective of this proposal is to explore in more detail the behavioral and computational significance of the modulatory influence of eye position on the processing of sound in the auditory pathway. Electrophysiological recordings of inferior colliculus neurons will be conducted in awake, behaving animals in order to characterize the interaction between eye position and auditory responses, and identify its role in sound localization behavior. Elucidating the nature of the interaction between eye position and auditory responses in the auditory pathway will help advance our understanding of the neural mechanisms that underlie cross-modal integration of sensory information, as well as contribute to the development of more rational therapeutic strategies for individuals with hearing dysfunction and other sensorimotor impairments.

刺激或事件的位置最初是用单独的参考框架（以醒目的为中心（或耳朵）为中心或身体为中心的）。为了协调和整合不同感觉系统收集的信息，大脑必须将信号转换为常见的参考框架。该实验室最近报告说，眼睛位置会影响某些神经元下丘和听觉皮层中某些神经元的听觉反应，但是这些区域中的参考框架介于头部和目击的参考框架之间。为什么大脑会以这种方式处理听觉空间？回答这个问题将使人们更好地了解大脑如何处理空间信息。因此，该提案的目的是更详细地探讨眼睛位置对听觉途径中声音处理的调节影响的行为和计算意义。下丘神经元的电生理记录将在清醒中进行，以表征眼睛位置和听觉反应之间的相互作用，并确定其在声音定位行为中的作用。阐明眼睛位置和听觉途径中听觉反应之间相互作用的性质将有助于我们对感官信息跨模式整合的神经机制的理解，并为具有更合理的治疗策略的发展促进具有听力障碍和其他感觉障碍障碍的人的更合理治疗策略。