GENETIC ANALYSIS CASE STUDIES OF MAJOR PSYCHOTIC ILLNESS

重大精神疾病的基因分析案例研究

• 批准号: 6276571
• 负责人: MARILYN A DAVIES
• 金额: $ 1.83万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6276571
• 关键词: bipolar depression; blood chemistry; clinical research; disease /disorder etiology; family genetics; genome; human subject; linkage mapping; molecular genetics; schizophrenia; statistics /biometry

The purpose of this project is to gather clinical and molecular genetic information from extended, highly informative families ascertained through well-diagnosed and well-characterized probands, in order to investigate, on a case to case basis, the role of genetics in the etiology of the major psychotic illness's. Specific Aims: 1) To systematically collect clinical and history data and blood samples for molecular genetic analysis. A sequential sampling design will be used to obtain the extended family information needed to address multiple hypotheses related to genetic etiology, anticipation and parent-of-origin effects. 2) To utilize clinical and laboratory data to search for evidence of susceptibility regions for bipolar disorder and schizophrenia. Linkage analysis will be utilized to assess previously implicated loci for possible confirmation, and to identify novel regions, both by consideration of candidate genes, and via a global genome search using a two-stage design. 3) To apply state of the art statistical genetic methods in order to assess genetic contributions to the complex etiology of bipolar disorder and schizophrenia, including possible anticipation and parent-of-origin effects.

该项目的目的是收集临床和分子遗传学 已查明来自信息丰富的大家庭的信息 通过充分诊断和充分表征的先证者，以便 根据具体情况调查遗传学在 主要精神病的病因学。 具体目标：1）系统收集临床和病史数据 和用于分子遗传分析的血液样本。 顺序采样 设计将用于获取大家庭所需的信息 解决与遗传病因学、预期相关的多种假设 和亲本效应。 2）利用临床和实验室 寻找双相情感障碍易感区域证据的数据 障碍和精神分裂症。 连锁分析将用于评估 先前涉及的位点以进行可能的确认，并确定 新的区域，既考虑候选基因，又通过 使用两阶段设计的全球基因组搜索。 3）应用状态 艺术统计遗传方法以评估遗传 对双相情感障碍复杂病因学的贡献 精神分裂症，包括可能的预期和父母的来源 影响。