EARLY ONSET BIPOLAR AFFECTIVE DISORDER GENETIC STUDY OF UNSTABLE DNA

早发性双相情感障碍不稳定 DNA 的遗传学研究

• 批准号: 6206108
• 负责人: MARILYN A DAVIES
• 金额: --
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6206108
• 关键词: biomedical resource; child (0-11); female; genetics; mental disorders; psychology; statistics /biometry

A series of behavioral checklists, administered to the parent, were used to characterize young girls with Fragile X Syndrome as well as a comparison group of developmentally delayed girls known to test negative for Fragile X. These included the Conners and Autism Checklists. The purpose of this project is to assess the relationship of the behavioral dimensions measured through these instruments, particularly hyperactivity and autism measures, with age and IQ, and to compare these relationships for the two groups. Results to date indicate a nonlinear relationship between age and IQ status, suggesting potential, nonadditive, effects of developmental stage and severity. Current efforts are focusing in characterizing these relationships through traditional regression modeling, classification and regression trees, and neural network approaches. Future efforts will include the development of predictive models for potential use in screening to identify individuals likely to have Fragile X Syndrome in developmentally delayed populations, with the aim of identifying candidates for DNA testing.

向家长提供一系列行为检查表， 也被用来描述患有脆性 X 综合症的年轻女孩 作为已知测试的发育迟缓女孩的对照组 脆性 X 呈阴性。其中包括康纳和自闭症 清单。 该项目的目的是评估关系 通过这些工具测量的行为维度， 特别是多动症和自闭症测量，与年龄和智商有关，以及 比较两组的这些关系。 迄今为止的结果 表明年龄和智商状态之间存在非线性关系， 表明发育阶段的潜在的、非累加的影响和 严重程度。 目前的工作重点是表征这些 通过传统回归建模、分类的关系 和回归树，以及神经网络方法。 未来的努力 将包括开发潜在用途的预测模型 筛查以确定可能患有脆性 X 综合症的个体 发育迟缓人群，目的是确定 DNA测试的候选人。