CHRONIC STRESS & HIPPOCAMPAL INTEGRITY IN ADOLESCENT DEPRESSION

慢性压力

• 批准号: 6477604
• 负责人: UMA RAO
• 金额: $ 4.85万
• 依托单位: UNIVERSITY OF CALIFORNIA LOS ANGELES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6477604
• 关键词: Mammalia; bioimaging /biomedical imaging; biomedical resource; computers; endocrine gland /system; magnetic resonance imaging; model design /development; nervous system; nuclear magnetic resonance spectroscopy; statistics /biometry

The hypothalamus and limbic system are widely thought to provide the neural substrates for motivation and emotion. although the organization of its connections, and indeed the definition of what structures should even be included within the limbic system, is poorly understood and controversial. The long range goal of our work on this topic, which is now in its twentieth year of funding, is to determine with neuroanatomical methods (combined pathway tracing and histochernistry for neurotransmission-related molecules) the precise topographical organization of pathways that interconnect the various nuclei of the hypothalamus, of pathways that innervate the hy hypothalamus from medial regions of the telencephalon (such as the amygdala and hippocampus), and of pathways that descend from the hypothalamus to brainstem and spinal cord to initiate various classes of instinctive. goal-oriented behavior (e.g.. ingestive, reproductive. and defensive). Specific Aims: 1. Generate a high resolution standard map of lateral hypothalamic regionalization, based on our computer graphics atlas of the rat brain. and on neurotransmitter gene expression patterns, cytoarchitecture, and previous connectional data. 2. Determine experimentally with combined axonal tracer/in situ hybridization methods the input/output relationships of each major lateral hypothalamic region.

下丘脑和边缘系统被广泛认为提供 动机和情感的神经底物。 虽然 其联系的组织，实际上是对什么的定义 结构甚至应包括在边缘系统中，很差 理解和有争议。 我们工作的远距离目标 现在已经在其20年的资金中的主题是确定 使用神经解剖学方法（组合途径跟踪和 与神经传递相关的分子的组织化学）精确 相互联系的路径的地形组织 下丘脑的核，支配hy的途径 脑脑内侧区域的下丘脑（例如 杏仁核和海马），以及从 下丘脑至脑干和脊髓，以启动各种类别 本能。 面向目标的行为（例如，摄取， 生殖。 和防御）。 具体目的： 1。产生下丘脑外侧的高分辨率标准图 区域化，基于我们的计算机图形图像 脑。 以及神经递质基因表达模式， 细胞结构和先前的连接数据。 2。确定 实验与轴突示踪剂组合/原位杂交 方法将每个主要侧面的输入/输出关系 下丘脑区域。