1H MRSI AND PERFUSION MRI OF SIVD

SIVD 的 1H MRSI 和灌注 MRI

• 批准号: 6472257
• 负责人: MICHAEL W WEINER
• 金额: $ 26.84万
• 依托单位: UNIVERSITY OF SOUTHERN CALIFORNIA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-15 至 2002-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6472257
• 关键词: Alzheimer's disease; aspartate; bioimaging /biomedical imaging; biomarker; brain disorder diagnosis; brain subcortex; cerebral ischemia /hypoxia; cerebrovascular imaging /visualization; clinical research; dementia; diagnosis design /evaluation; human old age (65+); human subject; infarct; magnetic resonance imaging; multiinfarct dementia; neural degeneration; postmortem; prognosis; stable isotope

Briefly, the findings of this project (total of 120 subjects, divided into 6 groups of 20 each) were: 1.) Reduced N-acetyl aspartate [NAA] in cortical gray matter (cGM) and hippocampus of demented patients (D) with lacunes (+L many of whom have subcortical ischemic vascular dementia (SIVD)) compared to elderly controls (CN), similar to changes in D without lacunes (many of whom have Alzheimer's). 2) Frontal cGM [NAA] was reduced to patients with thalamic lacunes, compared to those with non thalamic L. 3) cGM [NAA] was reduced in proportion to number of L and to % white matter lesions (WML). 4) MMSE and specific neuropsychological tests correlated with cGM [NAA]. Taken together, these finding strongly support the view that cGM [NAA] is reduced in D, and that this reduction is proportional in extent and location to subcortical infarction. We interpret the reduced cGM[NAA] to indicate either injury, reduced size, or reduced number, or cortical neurons, in response to subcortical infarction. This project will extend these findings by using short TE 1H MRSI to measure myo-inositol (a putative marker of Alzheimer's disease) and by using arterial spin labeled perfusion MRI to quantitate cortical and subcortical perfusion. The sample size will be about 60 subjects/group, followed autopsy for final pathological diagnosis of Alzheimer's and/or infarction. All subjects will have MRI with segmentation and hippocampal voluming, and multi-slice short TE 1H MRSI. Other related goals are to: 1.) Determine the relative extent that NAA, myoinositol, and perfusion are altered in SIVD and AD. 2.) To determine the relative extent to which subcortical infarction and cortical neuron damage contribute to dementia. 3.) To develop antemortem classification methods which reliably distinguish between SIVD and AD. 4.) To establish reliable products of cognitive decline in SIVD and AD. This project will help determine the effects of subcortical infarction on cognition, predict the effects of subcortical infarction our cognitive decline, and help distinguish between SIVD and AD. The significance is that this work will provide new understanding concerning the pathogenesis of SIVD and AD, improve the antemortem diagnosis of both disorders, and provide methods for evaluation the results of clinical treatment trials.

简而言之，该项目的发现（总计120名受试者分别为6组，每组20个）为：1。）减少了n-乙酰天冬氨酸[naA]在皮质灰质（CGM）和痴呆患者（D）的海马（d）中的N-乙酰基（naA）（+许多与皮层低皮层血管血管dementiv andiv）相同的（+l相比）（c相比）（c）缝隙（许多人都有阿尔茨海默氏症）。 2）与非丘脑L. 3）CGM [NaA]相比，丘脑腔腔的患者减少了额叶CGM [NAA]，与L的数量和白质病变（WML）成比例减少。 4）MMSE和特定的神经心理学测试与CGM [NAA]相关。综上所述，这些发现强烈支持了CGM [NaA]在D中减少的观点，并且这种降低的范围和位置与皮层梗死成正比。我们解释了降低的CGM [NAA]，以表明对皮层梗塞的损害，大小降低或数量减少或皮质神经元。该项目将通过使用简短的TE 1H MRSI来测量肌醇（阿尔茨海默氏病的推定标志），并使用动脉自旋标记的灌注MRI来定量皮质和皮层下灌注来扩展这些发现。样本量大约为60个受试者/组，尸检以最终病理诊断阿尔茨海默氏症和/或梗塞。所有受试者将具有分割和海马体积的MRI，以及多块短TE 1H MRSI。其他相关目标是：1。）确定NAA，肌醇和灌注在SIVD和AD中改变的相对程度。 2.）确定皮质下梗塞和皮质神经元损伤的相对程度有助于痴呆。 3.）开发可靠区分SIVD和AD的原生态分类方法。 4.）建立SIVD和AD认知能力下降的可靠产品。该项目将有助于确定皮层梗塞对认知的影响，预测皮层梗塞的影响我们的认知能力下降，并有助于区分SIVD和AD。意义在于，这项工作将提供有关SIVD和AD发病机理的新理解，改善两种疾病的原反面诊断，并提供评估临床治疗试验结果的方法。