CORE--DIAGNOSTIC

核心——诊断

• 批准号: 6618948
• 负责人: DORIS A TRAUNER
• 金额: $ 13.47万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN DIEGO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6618948
• 关键词: Downs syndrome; Williams syndrome; adolescence (12-20); autism; behavioral /social science research tag; biomedical facility; brain disorder diagnosis; brain injury; diagnosis service; human subject; language disorders; longitudinal human study; magnetic resonance imaging; medical outreach /case finding; mental disorder diagnosis; middle childhood (6-11); patient /disease registry; patient oriented research; preschool child (1-5); psychological tests; psychometrics; questionnaires

The Diagnostic Medical/Behavioral Core will provide a framework for the identification and neurobehavioral screening evaluation of subjects entering into the individual projects. Before the state-of-the-art experimental procedures outlined in Core C and in the Projects can be applied to the study populations, it is crucial to determine whether individual children meet the neurologic and behavioral criteria for the group to which they are assigned. In addition, the Core neurologic and behavioral information provides a framework in which to better understand the significance of the experimental behavioral data. The major responsibilities of the Neurobehavioral Core B are: 1. Identification and induction of experimental and control subjects. 2. Screening of subjects for selection criteria as defined for each research project. 3. Administration and analysis of medical and behavioral questionnaires and medical/neurologic examinations. 4. Administration and scoring of a standardized behavioral test battery to all experimental and control subjects. 5. Tracking of all subjects from entry to completion of testing. 6. Acquisition of MRI sans when appropriate, with clinical interpretations performed by a clinical neuroradiologist. 7. Collaboration with Project Investigators to relate these diagnostic findings to the experimental findings obtained in the Project studies.

诊断医学/行为核心将为进入各个项目的受试者的识别和神经行为筛查评估提供框架。在将核心 C 和项目中概述的最先进的实验程序应用于研究人群之前，确定个别儿童是否符合他们所分配的小组的神经和行为标准至关重要。此外，核心神经和行为信息提供了一个框架，可以更好地理解实验行为数据的重要性。神经行为核心 B 的主要职责是： 1. 实验和对照受试者的识别和诱导。 2. 根据每个研究项目定义的选择标准筛选受试者。 3. 医学和行为调查问卷以及医学/神经系统检查的管理和分析。 4. 对所有实验对象和对照对象进行标准化行为测试组的管理和评分。 5. 跟踪所有受试者从进入测试到完成测试的整个过程。 6. 适当时获取 MRI 图像，并由临床神经放射科医生进行临床解释。 7. 与项目研究人员合作，将这些诊断结果与项目研究中获​​得的实验结果联系起来。