CARCINOGENESIS AND NOVEL THERAPEUTICS IN ORAL CANCER

口腔癌的致癌作用和新疗法

• 批准号: 6468839
• 负责人: EVERETT E. VOKES
• 金额: $ 0.46万
• 依托单位: UNIVERSITY OF CHICAGO
• 依托单位国家: 美国
• 财政年份: 1996
• 资助国家: 美国
• 起止时间: 1996-09-30 至 2002-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6468839
• 关键词: carcinogenesis; oral pharyngeal neoplasm

There is a long history of oral cancer research in the Chicago area. In this application, the University of Chicago and Northwestern University are combining their efforts in laboratory and clinical sciences to foster interactions between laboratory scientists and clinical investigators, to generate new treatment hypothesis and conduct translational research in oral cancer. We will seek to optimize currently available therapy and improve the rehabilitation of the oral cancer patient. Our long-term goals are to identify new approaches to early diagnosis and more successful therapy based on an understanding of the molecular mechanisms underlying this disease. We will support pilot projects and the rapid generation of new clinical laboratory hypotheses utilizing developmental research funds provided by the grant and supplemented by the participating institutions and provide education and training in oral cancer research for basic and clinical investigators. The principal investigators have a long history of collaboration and have also conducted independent studies of oral carcinogenesis and cancer therapy and rehabilitation. Four projects are described in this application Project #1 will examine mechanisms underlying oral carcinogenesis that may identify tools for future early detection. Project #2 will study the role of apoptosis in oral carcinogenesis. Project #3 will study molecular pharmacokinetics of chemotherapy with concomitant radiotherapy in order to deliver more effective and less toxic therapy. Project #4 will measure organ function and rehabilitation in patients treated with curative intent chemoradiotherapy. Three pilot projects are also included which will be funded by the grant and matching funds made available by the two participating institutions. These activities will be supported by three cores. The administrative core, the biostatistical, data management and clinical core, and the tissue procurement and laboratory core. Core A, the administrative core will monitor ongoing projects, assure successful and timely performance of scientific tasks and interact with the internal and external advisory boards. Core B, the biostatistical data management and clinical core will provide expertise in data collection and analysis. Core C, the laboratory core will be responsible for the appropriate collection, preparation and distribution of human tissues required for ongoing projects.

芝加哥地区的口腔癌研究有着悠久的历史。 在 此应用程序，芝加哥大学和西北大学 正在结合实验室和临床科学的努力，以促进 实验室科学家和临床研究人员之间的互动， 产生新的治疗假设并进行转化研究 在口腔癌中。我们将寻求优化目前可用的治疗方法 改善口腔癌患者的康复。 我们的长期 目标是确定早期诊断的新方法等 基于对分子机制的理解的成功治疗 导致这种疾病的发生。我们将支持试点项目和快速实施 利用发育学产生新的临床实验室假设 研究经费由补助金提供并由 参与机构并提供口语教育和培训 基础和临床研究人员的癌症研究。校长 研究人员有着悠久的合作历史，并且还 进行口腔癌发生和癌症治疗的独立研究 和康复。本申请描述了四个项目 项目#1 将研究口腔癌发生的潜在机制 可以确定未来早期检测的工具。 项目#2 将研究 细胞凋亡在口腔癌发生中的作用。项目#3将研究分子 化疗联合放疗的药代动力学 提供更有效、毒性更低的治疗。项目 #4 将测量 接受治疗的患者的器官功能和康复 意向放化疗。还包括三个试点项目 将由两者提供的赠款和配套资金资助 参与机构。这些活动将得到三个机构的支持 核心。行政核心、生物统计、数据管理和 临床核心、组织采购和实验室核心。 核心 A，行政核心将监控正在进行的项目，确保 成功及时地执行科学任务并与 内部和外部顾问委员会。 核心B，生物统计 数据管理和临床核心将提供数据专业知识 收集和分析。 Core C，实验室核心负责 用于适当收集、准备和分发人类 正在进行的项目所需的组织。