CORE--ANALYTICAL FACILITY /AMINO ACIDS

核心--分析设施/氨基酸

• 批准号: 6450312
• 负责人: PAUL J FLAKOLL
• 金额: $ 11.77万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-01-01 至 2001-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6450312
• 关键词: aminoacid metabolism; analytical chemistry; biomedical facility; clinical research; dietary aminoacid; dietary trace element; dogs; high performance liquid chromatography; human subject; liquid chromatography mass spectrometry; nutrition; nutrition related tag

DESCRIPTION (adapted from the application): The Amino Acid Core Laboratory at Vanderbilt University was established in 1975 as a joint facility supported by the General Clinical Research Center (GCRC) and the Diabetes Research and Training Center (DRTC). The GCRC provided space and professional guidance (Dr. William Lacy), while the DRTC and GCRC jointly provided salary and supply support. In 1984, the Section of Surgical Sciences at Vanderbilt contributed to the further development of the Amino Acid Core laboratory by purchasing new equipment. The Core was organized under the direction of Dr. Naji Abumrad with special emphasis on the use of high performance liquid chromatography (HPLC) to assay amino acids. Dr. Lacy served as a consultant during this period. Over the next few years, new equipment was acquired and methods were developed in response to user demand for the measurement of a variety of labeled and unlabeled amino acids. With Dr. Lacy's untimely death in 1987, and the appointment of a new director of the GCRC, the Amino Acid Core was moved to space within the Section of Surgical Sciences. In 1984, the Vanderbilt CNRU joined the newly reorganized Amino Acid Core laboratory. In 1990, Dr. Paul Flakoll, Assistant Professor of Surgery, was appointed as director of the laboratory. Therefore, over the past 23 years the Amino Acid Core laboratory as evolved into a joint endeavor between the CNRU and the DRTC. This has resulted in greater efficiency, the offering of a wider range of services, and considerable financial savings. During its history, the core has progressed from a laboratory with two primary services (full amino acid profiles and alanine specific radioactivity) and three primary investigators to a laboratory with seventeen different services and sixteen investigators. Therefore, the core laboratory remains as a highly utilized and active component of the CNRU.

描述（根据应用程序改编）：AT的氨基酸核心实验室 范德比尔特大学（Vanderbilt University）成立于1975年，是由 一般临床研究中心（GCRC）和糖尿病研究和 培训中心（DRTC）。 GCRC提供了空间和专业指导（博士 William Lacy），而DRTC和GCRC共同提供薪水和供应 支持。 1984年，范德比尔特（Vanderbilt）的手术科学部分有助于 通过购买新的氨基酸核心实验室的进一步发展 设备。核心是在纳吉·阿布拉德博士的指导下组织的 特别强调使用高性能液相色谱法（HPLC） 测定氨基酸。 Lacy博士在此期间担任顾问。在 接下来的几年，获取了新设备，并开发了方法 对用户对测量各种标签的需求的响应和 未标记的氨基酸。莱西博士在1987年不合时宜地去世， 任命GCRC的新主管，氨基酸核心被移至 手术科学部分内的空间。 1984年，范德比尔特CNRU 加入了新重组的氨基酸核心实验室。保罗博士​​在1990年 手术助理教授Flakoll被任命为 实验室。因此，在过去的23年中，氨基酸核心实验室作为 演变成CNRU和DRTC之间的关节努力。这导致了 在更大的效率下，提供更广泛的服务，以及 大量的财务节省。在其历史上，核心已经发展 来自具有两个主要服务的实验室（全氨基酸剖面和 丙氨酸特异性放射性）和三名主要研究人员到实验室 有17个不同的服务和16名调查人员。因此， 核心实验室仍然是CNRU的高度利用和活跃成分。