Vascular Ultrasound Analysis Workstation

血管超声分析工作站

• 批准号: 6527233
• 负责人: JITKA SONKOVA
• 金额: $ 37.81万
• 依托单位: MEDICAL IMAGING APPLICATIONS, LLC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-19 至 2004-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6527233
• 关键词: bioimaging /biomedical imaging; biomedical automation; blood flow measurement; cardiovascular imaging /visualization; carotid artery; computer program /software; computer system design /evaluation; human data; image processing; vasodilatation

DESCRIPTION (Provided by Applicant):Small changes of vascular morphology or function are indicative of early stages of cardiovascular disease leading to coronary heart disease and stroke. Development of computerized methods for quantitative non-invasive assessment of the endothelial function, intima-media thickness, and compliance is important for early assessment of cardiovascular disease. During Phase I, we developed and validated a computerized method for diameter measurement in brachial ultrasound image sequences and demonstrated its feasibility for accurate quantitation of endothelial function. This Phase II proposal expands on the work done in Phase I to develop a comprehensive tool for early detection of atherosclerosis. The specific aims of Phase II are to: 1. Develop algorithms and methods for practical, accurate, and highly automated assessment of vascular flow-mediated vasodilation, intima-media thickness, and compliance. 2. Develop a Vascular Ultrasound Analysis Workstation that will allow user-friendly assessment of vascular dimensions and function. 3. Evaluate the accuracy and reproducibility of the workstation in standardized image data. This will allow employment in large population, pharmaceutical, and clinical studies. The developed tool will have the potential to identify subjects who are destined for atherosclerotic occlusive vascular disease. The final product will be available as a software package or an integrated turn-key computer station. PROPOSED COMMERCIAL APPLICATIONS: We expect that results of our Phase II research work will be commercialized in a similar fashion as the Phase I outcome. A commercialized Phase II software package will find its application among cardiovascular researchers for epidemiologic studies, cardiovascular researchers and pharmaceutical industry for drug-related trials, and clinicians for routine assessment of stroke risk via measurement of intima-media thickness. We also envision that developed software will be adopted by ultrasound manufacturers and become integral part of vascular ultrasound machines.

描述（由申请人提供）：血管形态的微小变化或 功能表明心血管疾病的早期阶段导致 冠心病和中风。开发计算机方法 内皮功能的定量非侵入性评估Intima-Media 厚度和依从性对于早期评估心血管很重要 疾病。 在第一阶段，我们开发并验证了直径的计算机化方法 臂超声图像序列的测量并证明了其 准确定量内皮功能的可行性。该阶段II 提案扩展了第一阶段中为开发全面工具所做的工作 用于早期检测动脉粥样硬化。 第二阶段的具体目的是： 1。开发实用，准确且高度自动化的算法和方法 评估血管流介导的血管舒张，内膜膜厚度和 遵守。 2。开发一个血管超声分析工作站，将允许 用户友好的血管维度和功能评估。 3。评估标准化工作站的准确性和可重复性 图像数据。这将允许大量人口，药物和 临床研究。 开发的工具将有潜力识别 注定要进行动脉粥样硬化的闭塞性血管疾病。最终产品将 可作为软件包或集成的交钥匙计算机站使用。 拟议的商业应用： 我们希望我们的第二阶段研究工作的结果将在类似的 时尚作为第一阶段的结果。 商业化的II期软件包将找到 它在心血管研究人员中的应用中用于流行病学研究，心血管 与药物有关的试验的研究人员和制药行业和常规的临床医生 通过测量内膜媒体厚度评估中风风险。 我们也设想 超声制造商将采用开发的软件 血管超声机的组成部分。