ARTERIAL ULTRASOUND ANALYSIS SOFTWARE PACKAGE

动脉超声分析软件包

• 批准号: 6017727
• 负责人: JITKA SONKOVA
• 金额: $ 9.78万
• 依托单位: MEDICAL IMAGING APPLICATIONS, LLC
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-08-19 至 2000-02-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6017727
• 关键词: angiography; bioimaging /biomedical imaging; biomedical automation; blood flow measurement; computer program /software; computer system design /evaluation; image processing; vasodilatation

This proposal will allow development of a robust, accurate, and validated software package for highly automated assessment of arterial flow mediated dilatation (FMD) from ultrasound images and image sequences. A commercially available software package with known behavior and assessed accuracy will become available for non-invasive assessment of endothelial dysfunction, one of the earliest indicators of cardiovascular disease. Assessment of FMD requires accurate determination of baseline artery diameter as well as continuous identification of diameter changes after obstructing the blood flow for a period of several minutes. Brachial arterial ultrasound is currently utilized but the developed methodology will be applicable to all peripheral vessels. The overall aim of the proposed research is to develop an automated method for analysis of arterial ultrasound images and image sequences. In addition, new morphological and functional indices related to FMD will be developed that would be potentially useful as early measures of the atherosclerotic process. The specific aims are to: 1. Develop a practical, robust, and accurate method for automated analysis ofarterial ultrasound image sequences. 2. Evaluate its accuracy and reproducibility in clinically acquired image data sets. The proposed methodology has the potential to identify subjects who are destined for atherosclerotic occlusive vascular disease. PROPOSED COMMERCIAL APPLICATIONS: The proposed software package will first be used by researchers studying endothelial function. Later, the software will become a low-cost tool for screening of patients to identify subjects with impaired endothelial function and will be located in almost every family practice office. While more than 6,000,000 U.S. patients have symptomatic coronary artery disease, many more adults have some degree of atherosclerotic narrowing of their coronary arteries. In 1991 stroke affected approximately 500,000 people, killing more than 143,000; peripheral vascular disease resulted in 267,000 hospitalizations and 42,000 deaths. The identification of high-risk individuals with subclinical disease is of major importance if preventive measures are to be instituted.

该提案将允许开发一个可靠，准确且经过验证的软件包，以从超声图像和图像序列中对动脉流介导的扩张（FMD）进行高度自动化评估。具有已知行为和评估精度的市售软件包将用于无创的内皮功能障碍，这是心血管疾病的最早指标之一。对FMD的评估需要准确确定基线动脉直径，并连续鉴定在阻塞血液流量几分钟后的直径变化。目前使用了臂动脉超声，但已开发的方法将适用于所有外围血管。拟议研究的总体目的是开发一种自动化方法，用于分析动脉超声图像和图像序列。此外，将开发与FMD相关的新形态学和功能指数，这可能是动脉粥样硬化过程的早期测量方法。具体目的是：1。开发一种实用，健壮且准确的方法，用于自动分析摩尔超声图像序列。 2。评估其在临床获取图像数据集中的准确性和可重复性。拟议的方法有可能识别注定针对动脉粥样硬化性血管疾病的受试者。拟议的商业应用：拟议的软件包将首先由研究内皮功能的研究人员使用。后来，该软件将成为筛查患者的低成本工具，以识别内皮功能受损的受试者，并将位于几乎每个家庭练习办公室。虽然超过6,000,000名美国患者患有有症状的冠状动脉疾病，但更多的成年人对冠状动脉造成了一定程度的动脉粥样硬化狭窄。 1991年，中风影响了约50万人，造成超过143,000人丧生；周围血管疾病导致267,000例住院和42,000人死亡。如果要采取预防措施，对患有亚临床疾病的高风险个体的鉴定至关重要。