MULTIELECTRODE ARRAYS FOR OLFACTORY INVESTIGATIONS

用于嗅觉研究的多电极阵列

• 批准号: 6516230
• 负责人: BRIAN W HATT
• 金额: $ 17.45万
• 依托单位: BIONIC TECHNOLOGIES, INC.
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-09-01 至 2002-08-20
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6516230
• 关键词: biomedical equipment development; biosensor device; brain electrical activity; computational neuroscience; electronic recording system; implant; laboratory rat; microelectrodes; olfactions; olfactory lobe; olfactory stimulus; sheep

DESCRIPTION(adapted from applicant's abstract): Of all human sensory modalities, those involving chemical detection (i.e. taste and smell), remain the least understood. Although a number of recent reports have been exciting in that they use various imaging modalities to investigate the spatial organization of olfactory bulb, there are currently no tools with which to simultaneously investigate the fine temporal and spatial structure of neural ensembles in the olfactory bulb. In Phase I, Bionic Technologies, Inc (BTI) successfully demonstrated the application of a microelectrode array to investigations of sensory processing in rat olfactory bulb. Building on these results, Phase II proposes to address several key issues in the deployment of this technology by the neuroscience community. In a unique collaboration with neuroscientists, BTI will: characterize and optimize the process of rapid pneumatic insertion, develop novel techniques for manipulating high electrode count arrays in situ, implement a chronic recording system for rats based on a new 16-pin high density connector, and investigate the manufacturing of novel multi-electrode architectures. These technologies will be evaluated in a series of acute experiments, conducted by the Center for Neural Interfaces at the University of Utah, designed to elucidate the interactions between large numbers of mitral cells during olfactory sensory processing. PROPOSED COMMERCIAL APPLICATION: Not Available

描述（根据申请人的摘要改编）： 方式，涉及化学检测的方式（即味道和气味）仍然存在 最不理解的。尽管最近的许多报告令人兴奋 他们使用各种成像方式来研究空间 组织嗅球的组织，目前没有任何工具 同时研究神经的精细时间和空间结构 嗅球中的合奏。在第一阶段，bionic Technologies，Inc（BTI） 成功证明了微电极阵列的应用 大鼠嗅球中感觉加工的研究。建立在这些基础上 结果，第二阶段建议解决部署的几个关键问题 神经科学社区的这项技术。与独特的合作 神经科学家，BTI将：表征和优化快速的过程 气动插入，开发用于操纵高电极的新技术 原位计数阵列，基于一个大鼠实现慢性记录系统 新的16针高密度连接器，并研究新颖的制造 多电极体系结构。这些技术将通过一系列评估 急性实验，由神经界面中心进行 犹他大学，旨在阐明大型之间的相互作用 嗅觉感觉过程中二尖瓣细胞的数量。 拟议的商业应用： 无法使用