A MOUSE BEHAVIORAL BATTERY FOR DOMAINS OF CNS FUNCTION

中枢神经系统功能领域的小鼠行为电池

• 批准号: 6362237
• 负责人: Richard E PAYLOR
• 金额: $ 22.36万
• 依托单位: BAYLOR COLLEGE OF MEDICINE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6362237
• 关键词: analgesia; anxiety; avoidance behavior; balance; behavior test; behavioral /social science research tag; behavioral genetics; compulsive behavior; conditioning; developmental psychology; diagnosis design /evaluation; ethology; exploratory behavior; fear; genetic strain; high throughput technology; laboratory mouse; learning; memory; mental disorder diagnosis; mental health information system; obsessive compulsive disorder; startle reaction

DESCRIPTION (Adapted from applicant's abstract): By virtue of the synteny between mouse and human, identifying genes that regulate behavioral responses in mice will provide important insights into the function of these genes in man. However, because behavioral responses are different between inbred strains of mice, the success of future studies using mouse models to identify genes underlying behavioral traits will require investigators to carefully choose the background strain for creating any particular mutation. Thus, it will be important for investigators to have sufficient information about the behavioral responses of different inbred strains of mice on a wide variety of assays. The objective of the research in this proposal is to characterize the behavioral responses of at least 6 inbred strains of mice on a wide variety of behavioral tests, and to develop a database that is easily accessed by investigators across the world. Three specific aims have been formulated to reach this objective. The first specific aim is to characterize the behavioral responses of inbred mice on a high-throughput behavioral test battery. The second aim is to develop clusters of behavioral assays specific to particular domains of CNS function that can be used as a secondary screen to further understand behavioral phenotypes of mutant mice. Six inbred strains will be characterized on each cluster developed under Specific Aim 2. The final specific aim is to characterize developmental profiles for several behavioral responses in different inbred strains of mice. Studying the development of behavior will provide important insights into the maturation of the processes underlying behavior, and will provide critical information for future studies with mutant mice that could eventually save thousands of research dollars. Findings from these aims will provide an important set of data on inbred strains of mice that will be critical to future studies developing mouse genetic models to better understand the genetic basis for several behavioral abnormalities associated with different human diseases.

描述（改编自申请人的摘要）：凭借同线性 在小鼠和人类之间，识别调节行为反应的基因 小鼠实验将为了解这些基因的功能提供重要的见解 男人。然而，由于近交系之间的行为反应不同 小鼠，使用小鼠模型识别基因的未来研究的成功 潜在的行为特征将需要研究人员仔细选择 用于产生任何特定突变的背景菌株。这样，将会是 对于调查人员来说，获得有关行为的足够信息很重要 不同近交系小鼠对多种测定的反应。这 本提案的研究目标是描述行为特征 至少 6 种近交系小鼠对多种行为的反应 测试，并开发一个易于研究人员访问的数据库 世界各地。为实现这一目标，制定了三个具体目标 客观的。第一个具体目标是描述行为反应的特征 高通量行为测试电池上的近交小鼠。第二个目标是 开发针对中枢神经系统特定领域的行为分析集群 可以作为副屏的功能，进一步了解 突变小鼠的行为表型。将鉴定六种近交系的特征 根据具体目标 2 制定的每个集群。最终的具体目标是 描述几种行为反应的发展概况 不同近交系小鼠。研究行为的发展将 提供有关基础流程成熟度的重要见解 行为，并将为未来的突变体研究提供关键信息 最终可以节省数千美元的研究资金的小鼠。调查结果来自 这些目标将提供一组关于近交系小鼠的重要数据， 对于未来开发小鼠遗传模型以更好地进行研究至关重要 了解几种相关行为异常的遗传基础 与不同的人类疾病。