NANOPOROUS INOGANIC BIOCAPSULES

纳米多孔无机生物胶囊

• 批准号: 6505984
• 负责人: Tejal A. Desai
• 金额: $ 10.26万
• 依托单位: BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6505984
• 关键词: aluminum; artificial membranes; biomaterial compatibility; biomaterial development /preparation; biomaterial evaluation; biomimetics; biotechnology; cell capsule; cell line; electric field; magnetic field; membrane permeability; molecular film; nanotechnology; physical separation; tissue engineering; titanium; ultrafiltration

DESCRIPTION (provided by applicant): The ability to create well-defined and controlled interfaces has been an area of great interest over the last few years, particularly in the biomedical arena. The goal of this research is to use innovative materials synthesis strategies to create both passive, and active, precision bioseparation membranes. Of particular interest to them is the development and characterization of well-controlled, stable, and uniform nano-dimensional membranes capable of the separation of viruses and/or proteins during the blood fractionation process and the blocking of antibodies and complement molecules from encapsulated xenogeneic cells. In such applications, the leakage of just one virus or antibody molecule through the membrane will compromise the entire system. It is hypothesized that high surface area cylindrical capsules, the walls of which are comprised of nanoporous membranes, created via electric-field driven anodization of aluminum or titanium can be used for the absolute filtration or exclusion of biomolecules in the nanometer range. Beyond making passive membranes, under the program auspices, nanoporous biocapsules incorporating magnetoelastic elements will be fabricated. The magnetoelastic elements enable the biocapsule to be mechanically vibrated, remotely from a distance, by application of a time varying magnetic field facilitating, and they believe ultimately allowing one to control, transport through the membrane. The proposed research project will focus on defining optimal routes for the fabrication of nanoporous capsules and the characterization of the material/structural properties of the nanoporous membranes with attention to film optimization and the functionality of the membranes as biological filters. The application of passive nanoporous biocapsules for cellular encapsulation/immunoisolation and magnetoelastic mechanically-active biocapsules for controlled transport through the nanoporous membranes will be investigated.

描述（由申请人提供）：创建明确定义和受控界面的能力在过去几年中一直是人们非常感兴趣的领域，特别是在生物医学领域。 这项研究的目标是利用创新的材料合成策略来制造被动和主动的精密生物分离膜。 他们特别感兴趣的是控制良好、稳定且均匀的纳米尺寸膜的开发和表征，该膜能够在血液分离过程中分离病毒和/或蛋白质，并从封装的异种细胞中阻断抗体和补体分子。 在此类应用中，仅一种病毒或抗体分子通过膜的泄漏就会危及整个系统。 据推测，高表面积圆柱形胶囊的壁由纳米多孔膜组成，通过电场驱动的铝或钛阳极氧化产生，可用于绝对过滤或排除纳米范围内的生物分子。 除了制造被动膜之外，在该计划的支持下，还将制造包含磁致弹性元件的纳米多孔生物胶囊。 磁致弹性元件使生物胶囊能够通过施加时变磁场促进远距离机械振动，他们相信最终允许人们控制通过膜的运输。 拟议的研究项目将侧重于确定纳米多孔胶囊制造的最佳路线以及纳米多孔膜的材料/结构特性的表征，同时关注薄膜优化和膜作为生物过滤器的功能。 将研究用于细胞封装/免疫隔离的被动纳米多孔生物胶囊和用于通过纳米多孔膜受控运输的磁致弹性机械活性生物胶囊的应用。