Visual motion processing in rewired cortex

重新连线皮层的视觉运动处理

• 批准号: 6525368
• 负责人: JESSICA R NEWTON
• 金额: $ 3.83万
• 依托单位: MASSACHUSETTS INSTITUTE OF TECHNOLOGY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-09-25 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6525368
• 关键词: auditory cortex; behavioral /social science research tag; electrophysiology; ferrets; intercellular connection; motion perception; neural information processing; neuroanatomy; single cell analysis; synapses; visual cortex; visual pathways; visual stimulus

DESCRIPTION (From the Applicant?s Abstract): This proposal focuses on the role of visual activity in the development of serial processing streams related to motion in cortex. A novel approach, developed in the sponsor?s laboratory, allows examination of ferret primary auditory cortex (A1) which is induced to receive visual information through the rerouting of retinal fibers in neonates. In these animals retinal axons are redirected to the medial geniculate nucleus (MGN) and through the intact thalamocortical pathway visual information is provided to A1. The proposed experiments will use optical imaging of intrinsic signals and single unit in vivo recordings to investigate the effects of visual activity on the representation of direction selectivity and the refinement of motion selectivity in the rewired auditory pathway. The degree of motion refinement from rewired A1 to subsequent stages of cortical processing, the anterior field (AF) and the ventral field (VF) will be compared to the degree of motion refinement in primary visual cortex and the secondary visual area, V2. Studies of the development of serial processing streams in the rewired auditory pathway may be relevant to understanding how processing streams develop in the normal visual cortex.

描述（来自申请人的摘要）： 该提案的重点是视觉活动在开发中的作用 与皮质运动有关的串行处理流。一种新颖的方法， 在赞助商的实验室中开发，允许检查雪貂主要 听觉皮层（A1）被诱导通过 新生儿视网膜纤维的重新路线。在这些动物中，视网膜轴突是 重定向到内侧基因核（MGN），并通过完整 丘脑皮层途径的视觉信息提供给A1。提议 实验将使用内在信号和单个单元的光学成像 体内记录研究视觉活动对 方向选择性的表示和运动的完善 选择性的听觉路径中的选择性。运动的程度 从重新连接的A​​1到随后的皮质加工阶段，前部场 （AF）和腹侧（VF）将与运动程度进行比较 初级视觉皮层和次级视觉区域V2的细化。研究 在重新连接的听觉路径中串行处理流的开发 可能与了解处理流在正常下的发展有关 视觉皮层。