Rheumatic Disease Research Core Center

风湿病研究核心中心

• 批准号: 6438550
• 负责人: ANDREW H KANG
• 金额: $ 55.01万
• 依托单位: UNIVERSITY OF TENNESSEE HEALTH SCI CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-28 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6438550
• 关键词: biomedical facility; rheumatoid arthritis

OVERALL CENTER DESCRIPTION (provided by applicant): We propose to establish a Rheumatic Diseases Research Core Center at the University of Tennessee Health Sciences Center, Memphis. Research in rheumatic diseases at this institution is characterized by a broad based, multidisciplinary collaboration involving several Departments. We have identified 26 scientists from 8 different Departments who share a common interest in rheumatic disease pathogenesis that will form the research base for this center. The theme of this proposal, "Extracellular matrix, Autoimmunity, Cytokines and their Receptors in Rheumatic Diseases", represents their interests and expertise. Individually, these investigators have been very successful and it is the goal of this center to coordinate their efforts in rheumatic disease research. The major objective of this proposal is to encourage rheumatic disease research by enhancing the interaction, efficiency, and productivity of the participating investigators; supporting novel research directions; attracting new investigators to the field; encouraging investigators in other disciplines to consider research in problems related to rheumatic diseases; and facilitating research involvement by clinical faculty and fellows. To support these objectives 3 cores are proposed. An Administrative Core will provide overall coordination, external review, and support for enrichment activities. A Molecular Resource Core will prepare collagen, provide state of the art gene quantitation and discovery, and perform HLA DQ and DR typing. An Animal Resources Core will provide well characterized transgenic and knock out mice, and flow cytometric analysis of cells involved in inflammation. Each of the cores will devote substantial effort to education and training in the use of modem methods and approaches to rheumatic disease research. We will establish a Pilot and Feasibility Program to encourage creative endeavors. Included in this application are 3 projects representing innovative proposals by new investigators. Recently, UTHSC designated Connective Tissue Research as a Center of Excellence and committed substantial support for new recruitment. This commitment will enhance our prospect for success. Strong institutional support for rheumatology, superior physical resources, and a favorable intellectual environment combine to make this an opportune time to establish an RDCC at this institution.

中心总体描述（由申请人提供）： 我们建议在该中心建立风湿病研究核心中心 田纳西大学健康科学中心，孟菲斯。风湿病研究 该机构的疾病特点是基础广泛、 涉及多个部门的多学科合作。我们有 确定了来自 8 个不同部门的 26 名科学家，他们有一个共同点 对风湿病发病机制的兴趣，这将成为以下研究的基础 这个中心。该提案的主题是“细胞外基质，自身免疫， 风湿病中的细胞因子及其受体”，代表了它们的 兴趣和专业知识。就个人而言，这些调查人员非常 成功，该中心的目标是协调他们的努力 风湿病研究。该提案的主要目标是 通过增强互动、效率、 以及参与研究人员的生产力；支持新颖的研究 方向；吸引新的研究人员来到该领域；鼓励 其他学科的研究人员考虑相关问题的研究 风湿性疾病；并促进临床教师的研究参与 和同胞们。为了支持这些目标，建议使用 3 个核心。一个 行政核心将提供总体协调、外部审查和 支持丰富活动。分子资源核心将准备 胶原蛋白，提供最先进的基因定量和发现，并执行 HLA DQ 和 DR 分型。动物资源核心将提供特征良好的 转基因和基因敲除小鼠，以及相关细胞的流式细胞术分析 处于炎症状态。每个核心都将在教育方面投入大量精力 以及使用现代方法和方法治疗风湿病的培训 研究。我们将建立一个试点和可行性计划来鼓励 创造性的努力。该申请中包括 3 个项目，分别代表 新研究人员提出的创新建议。最近，UTHSC 指定 结缔组织研究作为卓越中心并致力于 支持新的招聘。这一承诺将增强我们的前景 成功。风湿科强大的机构支持，优越的体质 资源优势和良好的智力环境相结合，使之成为 在该机构建立 RDCC 的时机恰到好处。