Microbial Pathogenesis and Host Inflammatory Responses

微生物发病机制和宿主炎症反应

• 批准号: 8216491
• 负责人: MARK S SMELTZER
• 金额: $ 198.28万
• 依托单位: UNIV OF ARKANSAS FOR MED SCIS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-15 至 2017-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8216491
• 关键词: Address; Antibiotic Resistance; Antimicrobial Resistance; Arkansas; Bacterial Infections; Biomedical Research; Center for Translational Science Activities; Centers of Research Excellence; Chronic; Chronic Disease; Clinical; Clinical Research; Communicable Diseases; Complex; Core Facility; Data Analyses; Development; Development Plans; Disease; Elements; Ensure; Environment; Faculty; Failure; Foundations; Funding; Goals; Grant; Health; Human; Immune response; Indium; Infection; Inflammatory Response; Medical; Mentors; Mentorship; National Center for Research Resources; Outcome; Pathogenesis; Pathology; Pediatric Hospitals; Play; Process; Recruitment Activity; Research; Research Infrastructure; Research Personnel; Resources; Rheumatoid Arthritis; Science; Scientist; Structure; TNFRSF5 gene; Translational Research; Universities; Viral; Virulence Factors; Virus Diseases; adverse outcome; antimicrobial drug; base; career; clinically relevant; interest; medical specialties; microbial; pathogen; programs; public health relevance; success; translational neuroscience

DESCRIPTION (provided by applicant): Addressing infectious disease in a therapeutically relevant fashion requires an understanding of both the microbial virulence factors that contribute to the disease process and how these factors impact the host immunological and inflammatory response to define the clinical outcome. Achieving this understanding provides a perfect opportunity for clinically relevant translational research and is the overriding theme of our proposed Center for Microbial Pathogenesis and Host Inflammatory Responses. The key element in the development of our Center is to bring together promising young investigators, each under the mentorship of established senior faculty, whose research is consistent with this scientific theme. The underlying hypothesis that ties these investigators together is that targeting diverse pathogens and pathogenic processes in an integrated, highly structured environment will optimize opportunities for the elucidation of common themes with respect to the host response and its adverse consequences on the disease process. To this end, this application brings together as Project Leaders junior investigators who focus on viral (Forrest), bacterial (Scurlock), and parasitic (Stumhofer) pathogens. Additionally, based on studies suggesting that persistent viral and bacterial infection plays a key role in the development of many chronic diseases, a fourth investigator (Ortmann) will focus on the host response in inflammatory arthritis, the principal example of which is rheumatoid arthritis. We propose to (Aim 1) enact an integrated and interactive faculty development plan for young investigators in the context of the underlying scientific theme with the immediate goal of leveraging the resources of the Center to enable these investigators to establish independent research careers and taking specific steps to ensure the absence of administrative or technical barriers to their success; (Aim 2) strengthen the biomedical research infrastructure on the host campuses of the University of Arkansas for Medical Sciences and Arkansas Children's Hospital; and (Aim 3) build on the success of these first two aims to recruit additional junior faculty and create the collaborative and synergistic environment required to establish a self-sustaining Center of Biomedical Research Excellence. As a means of further optimizing the academic, experimental, and translational synergy, specific consideration is also given to integration with existing NCRRfunded programs on the host campuses. These include the Arkansas INBRE, the UAMS CTSA Center for Clinical and Translational Research, and the Center for Translational Neuroscience, an established COBRE. Bringing all of these elements together will provide an integrated and supportive research infrastructure that will significantly enhance the ability of th Project Leaders to establish independent, extramurally funded research programs. The long-term goal is to integrate the Project Leaders included in this application with newly recruited junior investigators and with established investigators who can significantly expand their existing research programs in a manner consistent with the underlying scientific theme, to create the collaborative and translational synergy required for the development of successful program project applications and a self-sustaining translational research center that can impact human health.

描述（由申请人提供）：以治疗相关的方式解决传染病需要了解导致疾病过程的微生物毒力因素以及这些因素如何影响宿主免疫和炎症反应以定义临床结果。实现这一理解为临床相关转化研究提供了绝佳的机会，也是我们提议的微生物发病机制和宿主炎症反应中心的首要主题。我们中心发展的关键因素是汇集有前途的年轻研究人员，每个人都在资深教师的指导下，他们的研究与这一科学主题相一致。将这些研究人员联系在一起的基本假设是，在一个集成的、高度结构化的环境中针对不同的病原体和致病过程将优化阐明宿主反应及其对疾病过程的不利后果的共同主题的机会。为此，该应用程序汇集了作为项目负责人的初级研究人员，他们专注于病毒（Forrest）、细菌（Scurlock）和寄生虫（Stumhofer）病原体。此外，基于研究表明持续的病毒和细菌感染在许多慢性疾病的发展中起着关键作用，第四位研究者（Ortmann）将重点关注炎症性关节炎的宿主反应，其中主要的例子是类风湿性关节炎。我们建议（目标1）在基本科学主题的背景下为年轻研究者制定一项综合性、互动性的教师发展计划，近期目标是利用中心的资源，使这些研究者能够建立独立的研究生涯并采取具体步骤确保其成功不存在行政或技术障碍； （目标 2）加强阿肯色医学大学和阿肯色儿童医院主校区的生物医学研究基础设施； （目标 3）在前两个目标成功的基础上，招募更多的初级教师，并创造建立自我维持的生物医学卓越研究中心所需的协作和协同环境。作为进一步优化学术、实验和转化协同作用的一种手段，还特别考虑了与主办校区现有 NCRR 资助项目的整合。其中包括阿肯色州 INBRE、UAMS CTSA 临床和转化研究中心以及已成立的 COBRE 转化神经科学中心。将所有这些要素结合在一起将提供一个综合的、支持性的研究基础设施，这将显着增强项目负责人建立独立的、外部资助的研究项目的能力。长期目标是将本申请中包含的项目负责人与新招募的初级研究人员以及可以显着扩展其现有研究的现有研究人员整合起来 以与基本科学主题一致的方式开展研究计划，以创造开发成功的计划项目应用所需的协作和转化协同作用以及能够影响人类健康的自我维持的转化研究中心。