HEART RATE PATTERNS IN RHESUS W/ SELF INJURIOUS BEHAVIOR (SIB)

恒河猴自伤行为 (SIB) 的心率模式

• 批准号: 6453800
• 负责人: MELINDA NOVAK
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6453800
• 关键词: Mammalia; behavioral /social science research tag; carbohydrates; mental disorders; nervous system; psychology

Rhesus monkeys sometimes develop self-injurious behavior that may include occasional wounding (SIB) with frequent bouts of non-injurious, self-directed biting (NIB) Only a small percentage of individually housed monkeys acquire this condition suggesting that individual, genetically-based, characteristics may increase susceptibility in some monkeys Certain temperamental characteristics such as high reactivity and impulsivity are known to be genetically-based The purpose of this study was to determine if a high reactive temperament, characteristic of 20% of the rhesus monkey population, was associated with this disorder High reactors show heightened and prolonged physiological reactions to novel events and typically have high, stable heart rate patterms Heart rate and interbeat variability were examined in monkeys with a veterinary record of SIB (n=11) and in control monkeys (n=9) Monkeys were fitted with vests containing radiotelemetry units in the earl y afternoo n and had their heart rate monitored remotely for a 30-minute period the next morning After 18 minutes of baseline, the monkeys were exposed to novel sound (buzzer) three times at 3-minute intervals and then briefly observed a human carrying a net Heart rate decreased significantly during the first 18 minutes There was little reaction to the buzzer, but heart rate increased rapidly in response to the human carrying a net Neither heart rate nor interbeat variability differed in SIB and control monkeys However, heart rate did vary as a function of the occurrence of non-injurious biting Seven of 11 SIB monkeys engaged in non-injurious biting (NIB) during heart rate testing and had significantly higher heart rates than the 4 non-biting monkeys Two control monkeys also showed unusual reactions to the heart rate testing by exhibiting high levels of non-injurious biting These two subjects had significantly higher heart rates than all other monkeys In most primates, heart rat e is negatively correlated with interbeat variability This relationship was observed in nonbiting controls but not in the monkeys that directed non-injurious bites to themselves during the procedure These data fail to provide a link between SIB or NIB and high reactive temperament However, the data clearly show a dysregulation of heart function in self-biting monkeys with the uncoupling of heart rate and interbeat variability Further research will be aimed at determining whether self-directed biting produces dysregulation in heart rate activity

恒河猴有时会出现自残行为，这可能会导致 包括偶尔受伤 (SIB) 和频繁发作的 非伤害性、自我导向性咬合 (NIB) 仅一小部分 单独饲养的猴子会出现这种情况，这表明 个体的、基于基因的特征可能会增加 某些猴子的易感性 某些气质特征 例如众所周知的高反应性和冲动性 本研究的目的是确定高基因是否 反应性气质，20%的恒河猴的特征 高反应堆显示，与这种疾病有关 对新事件的增强和延长的生理反应 通常具有高且稳定的心率模式 心率和 兽医检查了猴子的心跳间变异性 SIB 记录 (n=11) 和对照猴子 (n=9) 猴子均已拟合 下午早些时候穿着装有无线电遥测装置的背心 并远程监测他们的心率 30 分钟 第二天早上，基线 18 分钟后，猴子暴露于 新颖的声音（蜂鸣器）3次，间隔3分钟，然后 短暂观察到一个人的净心率下降 前 18 分钟内反应显着 几乎没有反应 蜂鸣器响，但心率响应人类迅速增加 心率和心跳间变异性均无差异 然而，在 SIB 和对照猴子中，心率确实随着函数的变化而变化。 非伤害性咬伤发生率 11 只 SIB 猴子中的 7 只 在心率测试期间进行非伤害性咬合 (NIB) 以及 心率明显高于 4 只不咬人的猴子 两个 对照猴子也对心率表现出异常反应 通过表现出高水平的非伤害性咬合来进行测试这两个 受试者的心率明显高于所有其他猴子 在大多数灵长类动物中，心率 e 与心跳间隔呈负相关 变异性 在不咬人的对照组中观察到了这种关系，但是 那些对自己进行非伤害性咬伤的猴子则没有这种情况 在该过程中这些数据无法提供 SIB 或 NIB 和高反应性 然而，数据清楚地表明 自咬猴子的心脏功能失调 心率和心跳间变异性的解耦进一步研究 将旨在确定自我定向咬合是否会产生 心率活动失调