IMMUNOPATHOGENESIS OF MYCOBACTERIUM & SIV COINFECTION IN MACAQUES

分枝杆菌的免疫发病机制

• 批准号: 6453782
• 负责人: Zheng W Chen
• 金额: $ 11.11万
• 依托单位: HARVARD MEDICAL SCHOOL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6453782
• 关键词: AIDS; Mammalia; animal tissue; bacteria; communicable diseases; immunology; inflammation; lymphatic system; virus

Coinfection with HIV and Mycobacterium tuberculosis is associated with high rates of active tuberculosis and possibly an acceleration of the progression to clinical AIDS Elucidating the interplay of the immunopathogenic events that occur as a result of HIV/M tuberculosis coinfection is, therefore, of central importance for understanding the immune sequelae of this coinfection We have shown that macaques coinfected with SIV and Mycobacterium bovis Bacille Calmette-Guerin (BCG) develop a syndrome similar to AIDS-related tuberculosis Using this SIV/BCG coinfection model, we plan to study the immunopathogenesis of AIDS virus interactions with mycobacteria and the evolution of tuberculosis Publication Zou Z, Halloran M, Lee-Parritz D, Shen L, Simon M, Shen Y, Chen ZW In vivo effects of a bacterial superantigen on macaque TCR repertoires J Immunol, 160:5170-5180, 1998

HIV 和结核分枝杆菌的双重感染与 活动性结核病发病率高，并可能加速 临床艾滋病的进展 阐明艾滋病毒之间的相互作用 HIV/M 结核病导致的免疫致病事件 因此，合并感染对于理解 这种双重感染的免疫后遗症 我们已经证明，猕猴 与 SIV 和牛分枝杆菌卡介苗同时感染 (BCG) 出现类似于艾滋病相关结核病的综合征 使用 对于这种 SIV/BCG 双重感染模型，我们计划研究 艾滋病病毒与分枝杆菌相互作用的免疫发病机制 结核病的演变 出版物 Zou Z, Halloran M, Lee-Parritz D, Shen L, Simon M, Shen Y, Chen ZW 的体内效应 猕猴 TCR 库中的细菌超抗原 J 免疫学杂志， 160:5170-5180, 1998