ROLE OF INTERNEURONAL CIRCUITS IN HUMAN SPINAL CORD INJU

神经元回路在人类脊髓损伤中的作用

• 批准号: 6529659
• 负责人: BRIAN D SCHMIT
• 金额: $ 25.38万
• 依托单位: REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-28 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529659
• 关键词: central neural pathway /tract; clinical research; electromyography; electrostimulus; human subject; interneurons; neuromuscular function; neuromuscular stimulator; spasm; spinal cord injury

Interneuronal pathways play a significant role in the origin of spasticity in spinal cord injury (SCI.). Following SCI, the interruption of key descending spinal pathways results in uncontrolled reflex movements of the legs. These reflex movements consist of coordinated flexion or extension of the hip, knee and ankle in response to specific exteroceptive or proprioceptive cues. We postulate that SCI releases functional interneuronal circuits, making them accessible to afferent inputs. These circuits include interneuronal pathways responsible for the well-know flexion withdrawal reflex, which Is exaggerated in SCI, and the emergence of a novel reflex response, the extensor spasm. Knowledge of the afferent pathways and interneuronal systems responsible for flexor spasms is based on this analogy to the flexion withdrawal reflex. However, there is virtually no information about the origins of extensor spasms in SCI. Our first aim is to test whether flexor spasms are peripherally mediated by load-sensitive muscle afferents of the flexors. We postulate that hvperexcitability of the interneuronal pathways associated with load sensitive afferents could produce self excitation, effectively establishing a positive feedback loop. This mechanism would provide an explanation for the prolonged, repetitive muscle activation associated with flexor spasms. We will test this hypothesis in SCI subjects by altering the muscle load during the flexor reflex using muscle stimulation and imposed movements. Effects will be measured using joint torque and electromyographic measurements. For extensor spasms, we hypothesize that the observed motor behavior results from the release of spinal locomotor pathways following SCI. We will test this hypothesis by investigating whether extensor spasms are modulated by afferent information from hip flexors and ankle extensors. Since the proprioceptive hip flexor afferents and group lb ankle extensor afferents play a prominent role in the modulation of locomotion, by analogy we expect to show that extensor spasms are the manifestation of these locomotor reflexes. Extensor spasms will be quantified using a novel apparatus that measures the joint torque response to imposed movement triggers. The principles developed in this study will form the basis for new treatment modalities for spasticity in spinal cord injury.

神经元间通路在神经元的起源中起着重要作用 脊髓损伤（SCI）中的痉挛。 SCI之后，按键中断 脊髓下行通路导致不受控制的反射运动 腿。这些反射运动包括协调的屈曲或伸展 髋部、膝部和踝部对特定的外感受或本体感受的反应 提示。我们假设 SCI 释放了功能性的中间神经元回路，使得 它们可以接受传入输入。这些回路包括神经元间 负责众所周知的屈曲撤退反射的通路，这是 在 SCI 中被夸大，并且出现了一种新的反射反应，即伸肌 痉挛。了解传入通路和负责的神经元间系统 屈肌痉挛是基于与屈曲撤回反射的类比。 然而，几乎没有关于伸肌痉挛起源的信息 在SCI中。 我们的首要目标是测试屈肌痉挛是否是由外周介导的 屈肌的负荷敏感肌肉传入。我们假设 与负荷敏感相关的神经元间通路的过度兴奋性 传入可以产生自我激励，有效地建立积极的 反馈循环。这一机制将为长期的、 与屈肌痉挛相关的重复性肌肉激活。我们将测试这个 SCI 受试者通过改变屈肌反射期间的肌肉负荷进行的假设 使用肌肉刺激和强制运动。将使用以下方式衡量效果 关节扭矩和肌电图测量。 对于伸肌痉挛，我们假设观察到的运动行为导致 SCI 后脊髓运动通路的释放。我们将测试这个 通过研究伸肌痉挛是否受传入神经调节的假设 来自髋屈肌和踝伸肌的信息。由于髋关节本体感觉 屈肌传入神经和 lb 组踝伸肌传入神经在 运动的调节，通过类比，我们希望表明伸肌痉挛 是这些运动反射的表现。伸肌痉挛将会 使用一种测量关节扭矩响应的新颖装置进行量化 强加的运动触发器。 本研究中制定的原则将构成新治疗的基础 脊髓损伤痉挛的治疗方法。