VESICULAR SORTING BY GANGLIOSIDE GML IN INTESTINAL CELLS

肠细胞中神经节苷脂 GML 的囊泡分类

• 批准号: 6380347
• 负责人: Anne Armour Wolf
• 金额: $ 0.62万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-31 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6380347
• 关键词: cholera toxin; drug receptors; gangliosides; gastrointestinal epithelium; gastrointestinal toxin absorption; intracellular transport; pharmacokinetics; receptor binding; vesicle /vacuole

DESCRIPTION: This application focuses on vesicular sorting and the involvement of GM1 gangliosides in the cholera toxin-enterocyte interaction. The project is of some interest and the proposed studies should generate new information. The applicant is an outstanding candidate for further training and the project itself should provide an excellent vehicle for her training. The research environment is good, although a concern is that the mentor is training several post-doctoral candidates at the same time and many of them are on multi-authored papers. The concern is that this trainee have a unique area that she can be associated with following this training. Overall, this is an excellent to outstanding proposal.

描述：该应用程序重点关注囊泡分选和 GM1神经节苷脂参与霍乱毒素-肠细胞相互作用。 该项目具有一定的吸引力，拟议的研究应该会产生新的 信息。 申请人是进一步培训的优秀候选人 该项目本身应该为她的培训提供一个极好的工具。 研究环境不错，但导师不太好 同时培养博士后多名，且博士后人数众多 发表在多人撰写的论文上。 令人担忧的是，这名实习生有一个 通过这次培训，她可以与之相关的独特领域。 总的来说，这是一个优秀到杰出的提案。