IXth Nerve Anesthesis on Gustatory NTS Responses

味觉 NTS 反应的第九神经麻醉

• 批准号: 6445384
• 负责人: CHRISTIAN G REICH
• 金额: $ 2.3万
• 依托单位: STATE UNIVERSITY OF NY,BINGHAMTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-12-31 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6445384
• 关键词: albino rat; anesthesia; cranial nerves; electrophysiology; neural information processing; neurosurgery; predoctoral investigator; solitary tract nucleus; taste

DESCRIPTION (provided by applicant): The long-term goal of this study is to understand the neural processing of gustatory stimuli in the central nervous system. Of particular interest is the processing of appetitive (sweet) and aversive (bitter) stimuli in the medullary nucleus of the solitary tract (NTS). Information from appetitive stimuli is transmitted from the tongue to the NTS via the VIIth cranial nerve, whereas information regarding aversive stimuli is transmitted from the tongue to the NTS via the IXth nerve. Taste responses in the NTS are often the result of converging input from these two nerves. The functional nature of this convergence is not well understood, although some evidence suggests the presence of an inhibitory interaction between the VIIth and IXth nerves. The specific aim of this study is to investigate the role of the IXth nerve in this convergence and its influence on gustatory responses in the NTS. In order to study this, the IXth nerve will be selectively and reversibly anesthetized. Responses to the four basic taste stimuli (NaCl, sucrose, QHCl and HCl) will be recorded from single neurons in the NTS before, after and following recovery from IXth nerve anesthesia.

描述（由申请人提供）：本研究的长期目标是 了解中枢神经味觉刺激的神经处理 系统。特别令人感兴趣的是加工食欲（甜）和 孤束核（NTS）中的厌恶（苦味）刺激。 来自食欲刺激的信息从舌头传递到 NTS 通过第七脑神经，而有关厌恶刺激的信息是 通过第 IX 神经从舌头传输到 NTS。品尝反应 NTS 通常是这两条神经输入汇聚的结果。这 这种融合的功能本质还没有得到很好的理解，尽管有些 有证据表明，VIIth 之间存在抑制性相互作用 和第九神经。 本研究的具体目的是研究第 IX 神经在 这种趋同及其对 NTS 味觉反应的影响。为了 为了研究这一点，第九神经将被选择性地、可逆地麻醉。 对四种基本味觉刺激（NaCl、蔗糖、QHCl 和 HCl）的反应将是 恢复前、恢复后和恢复后 NTS 中单个神经元的记录 从第九神经麻醉。