CORE--RESEARCH ANIMAL SUPPORT FACILITY

核心——研究动物支持设施

• 批准号: 6481851
• 负责人: KENNETH N GRAY
• 金额: $ 25.41万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-08-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6481851
• 关键词: Drosophilidae; Macaca mulatta; SCID mouse; animal care; animal colony; biomedical facility; disease /disorder model; dogs; gene targeting; genetically modified animals; germ free condition; guinea pigs; laboratory mouse; laboratory rabbit; laboratory rat; sea urchins; swine; veterinary medicine

The Research Animal Support Facility (RASF) has been a shared resource since the original Cancer Center Support Grant (CCSG) was awarded in 1975. The University of Texas M.D. Anderson Cancer Center has supported the RASF over these years, using institutional funds for the acquisition of major operational equipment and for remodeling and utility upgrades. The RASF has two distinct sites. One is within the perimeter of the Texas Medical Center, and the other is approximately 1 mile south of the Texas Medical Center at the Smith Research Building. Both animal facilities are accredited by the Association for Assessment and Accreditation of Laboratory Animal Core International, have an approved Animal Welfare Assurance Form (A3343-01), and are part of a research facility registered with the United States Department of Agriculture (74-R-065). The RASF is composed of three specific-pathogen-free (SPF) general rodent barriers, an SPF transgenic mouse barrier, a biohazard-use facility, conventional rodent housing, large-animal housing (for monkeys, dogs, pigs, and rabbits) and quarantine facilities. The RASF maintains approximately 37,000 animals daily; 98% are rodents, most of which are mice. The remaining 2% are monkeys, dogs, pigs, rabbits, guinea pigs, hamsters, and frogs. Also used are sea urchins and fruit flies. Animals are used to answer questions about how to diagnose, treat, and prevent cancer and to understand its causes. Investigators in all 13 research departments and in 24 of 29 clinical departments are supported by the RASF. In addition, clinical, surgical, diagnostic imaging,, and irradiation facilities and services are provided, as are diagnostic and pathology laboratory facilities and services. Specific SPF facilities for severe combined immuno-deficiency (SCID) mice use are also provided, and new, expanded SPF facilities for knockout and transgenic mice production and use are being developed, with occupancy expected in about April, 1998.

研究动物支持设施（RASF）一直是共享资源 由于最初的癌症中心支持补助金（CCSG）于1975年获得。 德克萨斯大学医学博士安德森癌症中心已支持RASF 这些年来，使用机构资金来收购主要 操作设备以及改建和实用性升级。 RASF 有两个不同的站点。一个是在德克萨斯医疗的周边 中心，另一个位于德克萨斯州医疗以南约1英里处 史密斯研究大楼的中心。两个动物设施都是 获得评估和认证协会的认可 实验室动物核心国际，拥有批准的动物福利 保证表（A3343-01），是研究机构注册的一部分 与美国农业部（74-R-065）。 RASF是 由三个不含特异性病原体（SPF）的一般啮齿动物屏障组成 SPF转基因小鼠屏障，生物危害使用设施，常规 啮齿动物外壳，大动物住房（用于猴子，狗，猪和 兔子）和隔离设施。 RASF维护大约 每天37,000只动物； 98％是啮齿动物，其中大多数是小鼠。这 剩下的2％是猴子，狗，猪，兔子，豚鼠，仓鼠， 青蛙。还使用了海胆和水果蝇。动物习惯 回答有关如何诊断，治疗和预防癌症以及 了解其原因。所有13个研究部门的调查人员和 RASF支持29个临床部门中的24个。此外， 临床，手术，诊断成像和辐射设施以及 提供服务，诊断和病理实验室也是如此 设施和服务。严重合并的特定SPF设施 还提供了免疫缺陷（SCID）小鼠的使用，并扩大了新的SPF 淘汰和转基因小鼠的生产和使用的设施正在 开发，预计在1998年4月左右。