Brain Imaging of Tobacco Craving Using fMRI

使用功能磁共振成像对烟草渴望进行脑成像

• 批准号: 6317176
• 负责人: CHRIS-ELLYN JOHANSON
• 金额: $ 31.16万
• 依托单位: WAYNE STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-05-01 至 2004-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6317176
• 关键词: bioimaging /biomedical imaging; clinical research; craving; drug /alcohol abstinence; drug addiction; emotions; functional magnetic resonance imaging; human subject; neuropharmacology; nicotine; smoking; tobacco abuse

DESCRIPTION: (provided by applicant) Over this last decade, research on the significance of craving in understanding the neurobiological basis of addiction and for developing new therapies that specifically target craving has increased exponentially with special funding initiatives promulgated by both NIDA and NIAAA. Several investigators have embarked upon neuroimaging studies to identify the brain regions mediating the subjective and behavioral manifestations of craving. The purpose of this application is to utilize well-established imagery techniques for the elicitation of craving for cigarettes in conjunction with fMRI to identify the specific brain regions whose pattern of activation is associated with craving. One feature of the proposed research is the use of imagery procedures in which smoking-urge material is presented in a context that also produces positive, negative or neutral emotional mood states that are matched in terms of vividness. Those patterns of brain activation associated with craving, and independent of the emotional context, are of special interest. Prior research indicating the importance of limbic system activation during periods of drug craving will guide our research. However, the present design allows the determination of whether the emotional tone provoked by craving material is important in determining the pattern of brain activation. The results of this research will provide techniques for studying potential behavioral and pharmacological treatment interventions using both self-report of craving and fMRI patterns of brain activation as end points. Further, the development of reliable and valid self-report and fMRI techniques for studying the neural correlates of craving will permit future research examining how variables that modulate self-reported measures of craving change the pattern of brain activation. Those areas of brain activation that are most strongly associated with variations in self-reports of craving are most likely to be of functional significance and therefore potentially important end points for pharmacological interventions. Finally, because nicotine dependence is a prototypic addiction, this research should provide a model for similar research with other drug dependencies.

描述：（申请人提供）在过去的十年中，研究 渴望在理解成瘾的神经生物学基础上的重要性 并且为了开发专门针对渴望的新疗法已增加 NIDA和 NIAAA。一些研究人员已经开始了神经影像学研究 确定介导主观和行为的大脑区域 渴望的表现。此应用程序的目的是利用 建立了良好的图像技术，以激发人们的渴望 香烟与fMRI结合以识别特定的大脑区域 其激活模式与渴望有关。一个特征 拟议的研究是使用图像程序的使用 材料是在也会产生正面，负面或 中立的情绪状态以生动性匹配。那些 与渴望相关的大脑激活模式，与 情绪背景是特别感兴趣的。先前的研究表明 在毒品渴望期间，边缘系统激活的重要性将 指导我们的研究。但是，目前的设计允许确定 渴望材料引起的情感语气是否重要 确定大脑激活的模式。这项研究的结果将 提供研究潜在行为和药理的技术 使用渴望的自我报告和fMRI模式的治疗干预措施 大脑激活作为终点。此外，发展可靠和有效 用于研究渴望神经相关性的自我报告和功能磁共振成像技术 将允许未来的研究研究如何调节自我报告的变量 渴望的度量改变了大脑激活的模式。那些领域 大脑激活与变化最密切相关的大脑激活 渴望的自我报告最有可能具有功能意义，并且 因此，药理学干预措施的潜在重要终点。 最后，由于尼古丁依赖性是一种原型成瘾，因此这项研究 应提供与其他药物依赖性类似研究的模型。