"Why Do Whales Exist? Cancer Resistance in Mammals" - WCUB, ENWW

“鲸鱼为何存在？哺乳动物具有抗癌能力” - WCUB，ENWW

• 批准号: 1810131
• 金额: --
• 依托单位: University of Oxford
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2015
• 资助国家: 英国
• 起止时间: 2015 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1810131
• 关键词: Why; Do; Whales; Exist; Cancer

Exploring the ideas behind Peto's paradox and how mammal groups have evolved cancer resistance alongside life history traits.Investigating; i) genomic work exploring the evolution of cancer-associated gene redundancy and mutation in mammals, driving morphology and metabolism; ii) some sub-cellular modelling of cancer-associated proteins and networks to understand the implications of genetic change on physiology (ROS production etc.); iii) in vitro experiments on mammalian cells inc. collection Exploring the ideas behind Peto's paradox and how mammal groups have evolved cancer resistance alongside life history traits.BBSRC Priority areas:Data driven biology and also Exploiting New Ways of Working

探索Peto悖论背后的想法以及哺乳动物群体如何与人生历史特征一起发展癌症的抗性。 i）探索哺乳动物中与癌症相关的基因冗余和突变的演变的基因组工作，驱动形态和代谢； ii）对癌症相关蛋白和网络的某些亚细胞建模，以了解遗传变化对生理学的影响（ROS产生等）； iii）在哺乳动物细胞Inc的体外实验。收集探索Peto悖论背后的想法以及哺乳动物群体如何与人生历史特征一起发展癌症的耐药性。BBSRC优先领域：数据驱动的生物学以及利用新的工作方式