STATISTICAL METHODS FOR LONGITUDINAL AND OTHER STUDIES

纵向研究和其他研究的统计方法

• 批准号: 6432537
• 负责人: Kai F Yu
• 金额: --
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6432537
• 关键词: clinical research; data collection methodology /evaluation; disease /disorder proneness /risk; epidemiology; human data; longitudinal human study; perinatal; statistics /biometry

This project will investigate theory, methods and applications of mathematical statistics and probability, with particular emphasis on the problems with data collected by NICHD. Current focus is on the analysis of data arising from longitudinal studies with repeated measurements. Examples of NICHD projects on longitudinal studies are Small-for-Gestational Age Study I and Study II in Alabama and Scandinavia, Maternally Linked Longitudinal Studies in Missouri and Utah, Preventing Problem Behavior Among Middle School Students and Longitudinal Study of Vaginal Flora. A host of statistical procedures for estimation and hypothesis testing will be proposed and investigated for the time varying coefficient models via their asymptotic properties and simulations. Applications will be developed to handle questions concerning various issues in perinatal and reproductive epidemiology. New and rigorous statistical methods and algorithms will be generated and validated through investigation of their statistical and probabilistic properties. Computer-intensive techniques such as bootstrapping methodology will be investigated for the relevant problems. Among the applications of the developed methodology are fetal growth, maternal risk factors and pregnancy outcomes. Studying the attachments between children and care providers shortly before political reunification of the city. Comparative analyses show that infants were more likely to establish secure attachments to their care providers after reunification than before perhaps because care providers in the later regime focused on the styles and needs of individual infants. In a subsequently study, researchers observed in detail the everyday experiences of toddlers who either did or did not receive regular out-of-home care. The data showed different diurnal patterns of adult attention, stimulation, and emotional exchange, although the total amount of social interaction experienced over the course of the day did not differ depending on whether or not the toddlers spents time in day care. In the Berlin longitudinal study, researchers are assessing the psychophysiological and behavioral tendencies of infants in order to assess the effects of prior individual differences in emotional reactivity and infant-mother attachment on the adaptation to out-of-home center care. Preliminary analyses indicate that the securely attached infants had slower and more variable heart rates at day care when their mothers were present than insecurely attached infants did. The quality of infant-careprovider relations, infant-parent attachment, and infant temperament may all shape adaptation to day care.

该项目将研究数学统计和概率的理论，方法和应用，并特别强调NICHD收集的数据问题。 当前的重点是通过重复测量的纵向研究引起的数据分析。 纵向研究的NICHD项目的例子是阿拉巴马州和斯堪的纳维亚半岛的小胎龄研究I和研究II，在密苏里州和犹他州的母亲联系在一起，可防止中学生的问题行为以及阴道植物群的纵向研究。 将通过其渐近性能和模拟来提出大量用于估计和假设检验的统计程序。 将开发应用程序来处理有关围产期和生殖流行病学各种问题的问题。 通过研究其统计和概率特性，将生成和验证新的和严格的统计方法和算法。将针对相关问题研究计算机密集型技术，例如引导方法。 在开发方法的应用中，有胎儿的生长，母体危险因素和妊娠结局。在城市政治统一之前不久，研究儿童与护理提供者之间的依恋。 比较分析表明，在统一后，婴儿更有可能与以前的护理提供者建立安全的依恋，因为后来政权的护理提供者着重于个别婴儿的样式和需求。 在随后的一项研究中，研究人员详细观察了那些曾经或未获得定期户外护理的幼儿的日常经历。 数据显示出不同的成人注意力，刺激和情绪交流的昼夜模式，尽管一天中经历的社交互动总量并没有根据日托中的幼儿长时间的时间而有所不同。在柏林纵向研究中，研究人员正在评估婴儿的心理生理和行为倾向，以评估先前个体差异在情绪反应性和婴儿母亲依恋对户外中心护理适应性的影响。初步分析表明，在母亲在场时，牢固的婴儿在日托时的心率较慢，并且比不安全的婴儿时的心率较慢。 婴儿 - 挑剔的关系，婴儿恋爱的依恋和婴儿气质的质量都可能塑造对日托的适应性。