Quality of Life Children with HIV Infection

HIV 感染儿童的生活质量

• 批准号: 6529033
• 负责人: DEBORAH S STORM
• 金额: $ 33.07万
• 依托单位: UNIV OF MED/DENT OF NJ-SCHOOL OF NURSING
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529033
• 关键词: AIDS therapy; HIV infections; adolescence (12-20); behavioral /social science research tag; child (0-11); clinical research; epidemiology; health behavior; health care service utilization; human data; longitudinal human study; nursing research; pediatric AIDS; quality of life; social behavior; socioeconomics

DESCRIPTION: The widespread use of antiretroviral therapy has significantly reduced both mortality and morbidity from perinatally acquired HIV infection in the developed world. HIV infection is now considered a chronic condition and many, if not most children, are living to adulthood. Assessment of health related quality of life (QOL) provides a framework to integrate objective indicators and health and illness with the lived experience of, orsubjective reality, of children, youth, and their families. An understanding of the impact of the disease and its treatment on QOL is needed to develop research based nursing interventions. The specific aims of the project are to 1) characterize QOL and longitudinal patterns of change in QOL outcomes in children and youth with HIV infection 2) identify demographic, social, disease status, treatment, and health care utilization factors that predict longitudinal changes in QOL outcomes 3) develop a conceptual model that characterizes the effects of specific factors that predict longitudinal changes in QOL and 4) characterize the influence of HIV symptoms on QOL outcomes in the domains of health perceptions, physical, psychological, and social role functioning. A collaboration of the School of Nursing at the University of Medicine and Dentistry of New Jersey and the Graduate School of Nursing, University of Massachusetts at Worcester, this study will use national data available through a prospective, observational, longitudinal study of children and youth (n=1,993) from birth to 25 years with HIV infection (Pediatric AIDS Clinical Trials Group Protocol 219/219C). Knowledge development about QOL and the factors that affect it is a prerequisite to implementing effective nursing interventions and clinical programs to support and improve QOL in this vulnerable population of children. The findings will be of significant use to nurses and other health care providers, researchers, insurers, and policy makers throughout the world.

描述：抗逆转录病毒疗法的广泛使用已显着 降低了围产期艾滋病毒感染的死亡率和发病率 发达国家。 HIV 感染现在被认为是一种慢性病，并且 许多（如果不是大多数）儿童都能活到成年。健康评估 相关生活质量 (QOL) 提供了一个框架来整合目标 指标以及健康和疾病与生活经验或主观 儿童、青少年及其家庭的现实。了解影响 需要对该疾病及其对生活质量的治疗进行基于研究的开发 护理干预。该项目的具体目标是 1) 描述 儿童和青少年的生活质量和生活质量结果的纵向变化模式 HIV 感染 2) 确定人口、社会、疾病状况、治疗、 以及预测生活质量纵向变化的医疗保健利用因素 结果 3) 开发一个概念模型来描述以下效果的特征 预测 QOL 纵向变化的具体因素和 4) 表征 HIV 症状对健康领域 QOL 结果的影响 感知、身体、心理和社会角色功能。一个 医学院和护理学院的合作 新泽西州牙科和护理研究生院，大学 马萨诸塞州伍斯特市，这项研究将使用通过以下途径获得的国家数据： 针对儿童和青少年的前瞻性、观察性、纵向研究 (n=1,993) 从出生到 25 岁患有 HIV 感染（儿科艾滋病临床 试验组方案 219/219C）。有关 QOL 和 影响因素是实施有效护理的前提 支持和改善生活质量的干预措施和临床计划 儿童弱势群体。研究结果将具有重要意义 护士和其他医疗保健提供者、研究人员、保险公司和政策 世界各地的制造商。