Learning & memory dependent encoding in the hippocampus

学习

• 批准号: 6464926
• 负责人: Matthew L Shapiro
• 金额: $ 38.14万
• 依托单位: ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-15 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6464926
• 关键词: NMDA receptors; action potentials; behavior test; behavioral /social science research tag; brain electrical activity; caudate nucleus; cognition; electrical measurement; electrophysiology; hippocampus; inhibitor /antagonist; laboratory rat; learning; long term potentiation; memory; motivation; neural information processing; neural plasticity; neuroanatomy; neuromuscular system; neurophysiology; neuropsychological tests; olfactory stimulus; preference; psychomotor function; space perception; time resolved data

DESCRIPTION (provided by applicant): Memory is crucial to identity and survival, and the hippocampus is required for normal memory. The causal relationship between hippocampal cell activity and learning and memory performance, however, remains unknown because few experiments record neuronal firing while memory demands are varied and other aspects of behavior are held constant. Aim 1. To identify learning-dependent changes in neuronal encoding by recording groups of hippocampal neurons while rats perform a task that requires the hippocampus. Successful newlearning that requires the hippocampus should require the formation of new and persistent firing patterns by hippocampal neurons. Rats will be trained in a + maze task that can be solved by either hippocampus-dependent or independent strategies. Groups of hippocampal cells will be recorded in rats that behave identically but differ in learning ability, memory strategy, and hippocampal function. Probes will test the strategies used by each rat, and unit activity will be compared in normal place and response learners, and rats with fornix or caudate lesions. Aim 2. To test the generality of the results in Aim 1, neuronal activity will be recorded in rats trained in a distinct type of learning, the social transmission of food preference. A subset of dynamic neuronal responses may be required for all types of hippocampus-dependent learning, independent of behavioral expression, type of motivation, and specific content of learning. Hippocampal neurons in normal rats should develop persistent olfactory associations between the arbitrarily selected novel food odors and the odor of carbon disulfide, the signal of food safety. Aim 3. To test if temporal relationships among spike trains encode memory by comparing real-time ensemble activity in the hippocampus. Significant memory information may be encoded by the temporal relationships among neurons action potentials. The temporal dynamics of spiking within ensembles recorded during identical behaviors but different memoryloads will be assessed using published and a new method. The analysis will begin by comparing spike records as rats traverse the start arm of a + maze during right and left turns.

描述（由申请人提供）：内存对于身份和 生存和海马是正常记忆所必需的。因果关系 海马细胞活动与学习与记忆之间的关系 但是，性能仍然未知，因为很少有实验记录神经元 在记忆需求的同时发射，行为的其他方面 持续的。目的1。通过 大鼠执行需要的任务时，记录海马神经元的组 海马。成功的新学习需要海马应 需要海马形成新的和持续的射击模式 神经元。大鼠将接受 +迷宫任务的训练 海马依赖或独立策略。海马细胞组 将记录在行为相同但学习不同的老鼠中 能力，记忆策略和海马功能。探针将测试 每只大鼠使用的策略和单位活动将在正常位置进行比较 和反应学习者，以及带有前虫或尾状病变的大鼠。目标2。测试 AIM 1中结果的普遍性，将记录在 接受过独特学习类型的训练的大鼠，食物的社会传播 偏爱。所有人都可能需要一个动态神经元反应的子集 海马依赖性学习的类型，独立于行为表达， 动机的类型和特定的学习内容。海马神经元 正常大鼠应发展 任意选择新的食物气味和二硫碳的气味， 食品安全的信号。目标3。测试尖峰之间的时间关系是否 火车通过比较实时合奏活动来编码内存 海马。大量的内存信息可以通过时间来编码 神经元动作潜力之间的关系。尖峰的时间动态 在相同行为中记录的合奏中，但内存负载不同 将使用已发布的新方法进行评估。分析将从 将尖峰记录比较，因为大鼠在右边横穿A +迷宫的起始臂 和左转。