fMRI and neuronal activity in awake behaving macaques

清醒行为猕猴的功能磁共振成像和神经元活动

• 批准号: 6552920
• 负责人: ROGER B TOOTELL
• 金额: $ 49.33万
• 依托单位: MASSACHUSETTS GENERAL HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-15 至 2007-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6552920
• 关键词: Macaca; bioimaging /biomedical imaging; electrophysiology; functional magnetic resonance imaging; motion perception; neural conduction; neural information processing; neuroimaging; neurons; visual cortex; visual fields; visual perception

DESCRIPTION (provided by applicant): Recently there has been an enormous increase in knowledge about the human brain, based on functional magnetic resonance imaging (fMRI) and related techniques. Unfortunately, fMRI does not measure neural activity directly; it only measures the response of adjacent blood vessels to the neural activity of interest. Without additional information it is difficult to interpret the local electrical activity of the neurons themselves. The proposed experiments are designed to fill this knowledge gap by directly comparing neural activity to the fMRI results, in awake behaving macaque monkeys. We plan three specific aims, in progressively higher-order regions of visual cortex, as a 'bottom-up' approach to understanding the fMRI-neural response relationship at different levels of information processing complexity. First, in primary visual cortex (area V1), we will re-test previous predictions about the neural-fMRI relationship in awake behaving macaques, and compare the extent of electrical and fMRI activity in retinotopic (visual field) coordinates. Secondly we will test the neural-fMRI relationship in MT, a visual area specialized for processing visual motion, using motion adaptation to reveal direction-selective responses. Finally, we will test the neural-fMRI relationship in a higher-order region of visual cortex which appears to be specialized for processing faces and other visual objects.

描述（由申请人提供）： 最近，基于功能性磁共振成像（fMRI）和相关技术，人们对人脑的知识有很大增加。不幸的是，fMRI不能直接测量神经活动。它仅测量相邻血管对感兴趣的神经活动的反应。没有其他信息，很难解释神经元本身的局部电活动。提出的实验旨在通过将神经活动与fMRI结果直接比较，以填补这一知识差距，以唤醒表现出猕猴。我们计划在视觉皮层的逐渐高阶区域中的三个特定目标，作为一种“自下而上”的方法，用于理解不同信息处理复杂性不同级别的fmri-nural响应关系。首先，在原发性视觉皮层（区域V1）中，我们将重新测试先前关于锯齿状猕猴中神经-FMRI关系的预测，并比较视网膜（视野）坐标中电和fMRI活性的程度。其次，我们将测试MT中的神经-FMRI关系，MT是一个专门用于处理视觉运动的视觉区域，使用运动适应来揭示方向选择性响应。最后，我们将在视觉皮层的高阶区域中测试神经-FMRI的关系，该关系似乎专门用于处理面部和其他视觉对象。