THE PREVALENCE AND CLINICAL CHARACTERISTICS OF CYSTIC FIBROSIS ARTHROPATHY

囊性纤维化关节病的患病率和临床特征

• 批准号: 6220556
• 负责人: ROBERT SUNDEL
• 金额: $ 0.07万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-12-01 至 1999-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6220556
• 关键词: clinical research; cystic fibrosis; epidemiology; human subject; joint disorder; longitudinal human study; medical complication; pathologic process; polyarthritis; prognosis

A prospective study of the prevalence, incidence, clinical characteristics, prognostic features, and pathologic description of cystic fibrosis arthropathy (CFA). CFA is characterized by recurrent, often painful bouts of mono-or polyarthritis. Many patients also manifest an erythema-nodosum-like rash, or in a few cases, purpuric skin lesions. The flares of joint inflammation last from one day to several weeks. Some patients with CFA progress to a chronic arthritis that can be quite debilitating. The appropriate treatment of CFA is not known and has not been studied in a large prospective study. The study is being performed simultaneously at Children's Hospital and The Massachusetts General Hospital as a combined effort of the Rheumatology Departments and Cystic Fibrosis Centers at each institution. The study entails screening for the presence of CFA with a questionnaire and follow-up medical chart review, physical exam, laboratory tests and selective radiographs. The study seeks to advance both the clinical and basic scientific knowledge of CFA and possibly gain insight into possible preventive or treatment measures.

一项关于囊性纤维化关节病 (CFA) 的患病率、发病率、临床特征、预后特征和病理描述的前瞻性研究。 CFA 的特点是反复发作、常常伴有疼痛的单关节炎或多关节炎。 许多患者还表现出结节性红斑样皮疹，或在少数情况下出现紫癜性皮损。 关节炎症的发作持续一天到几周。 一些 CFA 患者会发展为慢性关节炎，使人变得非常虚弱。 CFA 的适当治疗尚不清楚，也没有在大型前瞻性研究中进行过研究。 该研究是儿童医院和马萨诸塞州总医院风湿病科和囊性纤维化中心共同努力的同时进行的。 该研究需要通过问卷调查和后续病历审查、体检、实验室测试和选择性射线照相来筛查 CFA 的存在。 该研究旨在提高 CFA 的临床和基础科学知识，并可能深入了解可能的预防或治疗措施。