THE PREVALENCE AND CLINICAL CHARACTERISTICS OF CYSTIC FIBROSIS ARTHROPATHY

囊性纤维化关节病的患病率和临床特征

• 批准号: 6281395
• 负责人: ROBERT SUNDEL
• 金额: $ 2.01万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-12-01 至 1998-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6281395
• 关键词: clinical research; cystic fibrosis; epidemiology; human subject; joint disorder; longitudinal human study; medical complication; pathologic process; polyarthritis; prognosis

A prospective study of the prevalence, incidence, clinical characteristics, prognostic features, and pathologic description of cystic fibrosis arthropathy (CFA). CFA is characterized by recurrent, often painful bouts of mono-or polyarthritis. Many patients also manifest an erythema-nodosum-like rash, or in a few cases, purpuric skin lesions. The flares of joint inflammation last from one day to several weeks. Some patients with CFA progress to a chronic arthritis that can be quite debilitating. The appropriate treatment of CFA is not known and has not been studied in a large prospective study. The study is being performed simultaneously at Children's Hospital and The Massachusetts General Hospital as a combined effort of the Rheumatology Departments and Cystic Fibrosis Centers at each institution. The study entails screening for the presence of CFA with a questionnaire and follow-up medical chart review, physical exam, laboratory tests and selective radiographs. The study seeks to advance both the clinical and basic scientific knowledge of CFA and possibly gain insight into possible preventive or treatment measures.

一项关于患病率、发生率、临床的前瞻性研究 特征、预后特征和病理描述 囊性纤维化关节病（CFA）。 CFA的特点是反复出现， 经常出现单关节炎或多关节炎的痛苦发作。很多患者还 表现为结节性红斑样皮疹，少数情况下表现为紫癜 皮肤损伤。关节炎症的发作持续一天至 几个星期。一些 CFA 患者进展为慢性关节炎 这可能会让人非常虚弱。 CFA 的适当治疗并不 已知且尚未在大型前瞻性研究中进行研究。研究 正在儿童医院和儿童医院同时进行 马萨诸塞州总医院是风湿病科的共同努力 每个机构的部门和囊性纤维化中心。研究 需要通过问卷调查来筛查 CFA 的存在，并且 后续病历审查、体检、实验室测试和 选择性放射线照片。该研究旨在推进临床和 CFA 的基本科学知识，并可能深入了解 可能的预防或治疗措施。