CARDIOVASCULAR DISEASE & PERIODONTAL DISEASE UNDERLYING GENETIC SUSCEPTIBILITY?

心血管疾病

• 批准号: 6491954
• 负责人: STEPHEN WOTMAN
• 金额: $ 29.46万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-01 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6491954
• 关键词: biomedical resource; child (0-11); epidemiology; female; genetics; human subject; immunology; inflammation; male; oral pharyngeal

The object of this study is the assessment of patterns of infection with microbial pathogens linked to periodontal disease in families participating in the Multigenerational Study of Periodontitis in the Piedmont area of North Carolina. The study sample includes members of nuclear families ascertained through individuals studied as part of a population-based epidemiologic study of elder North Carolinians, regardless of periodontal status. Clinical, behavioral, and immunological measures were obtained for study. In a subset of these persons, who were found to have severe periodontal disease, extended family structures were sampled. Analyses to date provide evidence of significant levels of familial aggregation of infection status, with stronger levels of maternal than paternal association. Analyses incorporating adjustment for relevant covariates are in progress.

这项研究的目的是评估模式 与牙周疾病有关的微生物病原体感染 参加牙周炎多代研究的家庭 在北卡罗来纳州的皮埃蒙特地区。 研究样本包括 核心家庭成员通过研究的个人确定 基于人群的流行病学研究的一部分 卡罗来纳州，无论牙周状态如何。 临床，行为， 并获得了免疫学措施进行研究。 在一个子集中 这些人被发现患有严重的牙周疾病， 取样了扩展的家庭结构。 迄今为止提供的分析 感染的家族聚集水平的证据 状态，母体水平高于父亲的关联。 结合了相关协变量调整的分析已在 进步。