EYE GROWTH DURING INFANCY

婴儿期眼睛的生长

• 批准号: 6288148
• 负责人: SCOTT R LAMBERT
• 金额: $ 8.51万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2000-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6288148
• 关键词: Mammalia; behavioral /social science research tag; congenital disorders; eye; growth /development; nervous system; psychology; vision

Most of the axial growth of the eye occurs during the first two years of life. While the growth of the eye is usually precisely regulated by a process known as emmetropization, this process can become deranged in certain conditions resulting in excessive or retarded axial growth and large refractive errors. This project seeks to elucidate the molecular mechanisms responsible for the physiological processes that cause aberrant ocular growth with aphakia. Specifically, we will assay infantile eyes for changes in certain neurotransmitters and growth factors after removing the crystalline lens which we have previously shown retards ocular growth. Understanding the mechanisms whereby aphakia alters ocular growth is of vital importance to accurately select the most appropriate intraocular lens power to implant into infantile eyes after cataract surgery. In addition, by understanding the mechanisms retarding ocular growth, it may be possible to modulate the excessive ocular gro wth which occurs in certain pathological conditions such as retinopathy of prematurity. FUNDING NIH EY08544 $156,904 9/30/98 - 1/31/02 PUBLICATIONS None P51RR00165-38 1/1/98 - 12/31/98 Yerkes Regional Primate Research Center

眼睛的大部分轴向生长发生在前两个阶段 生命的岁月。 虽然眼睛的生长通常是精确的 由称为正视化的过程调节，该过程可以 在某些情况下变得精神错乱，导致过度或 眼轴生长迟缓和屈光不正大。 该项目寻求 阐明负责的分子机制 导致眼睛异常生长的生理过程 无晶体眼。 具体来说，我们将检测婴儿眼睛的变化 去除后某些神经递质和生长因子 我们之前已经证明晶状体会阻碍眼睛的生长。 了解无晶体眼改变眼睛生长的机制是 准确选择最合适的方案至关重要 白内障后植入婴儿眼睛的人工晶状体能力 外科手术。 此外，通过了解阻碍机制 眼部生长，可能可以调节过度的眼部生长 发生在某些病理条件下，例如 早产儿视网膜病变。 资金 NIH EY08544 $156,904 9/30/98 - 2002 年 1 月 31 日出版物 无 P51RR00165-38 1/1/98 - 12/31/98 Yerkes 区域灵长类动物研究中心