PREVALENCE OF PREMENSTRUAL DYSPHORIC DISORDER

经前焦虑症的患病率

• 批准号: 6420969
• 负责人: SHIRLEY ANN HARTLAGE
• 金额: $ 10.85万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2002-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6420969
• 关键词: behavioral /social science research tag; case history; clinical depression; clinical research; disease /disorder classification; female; human middle age (35-64); human subject; interview; major depression; menstrual cycle; mental disorder diagnosis; mental health epidemiology; premenstrual syndrome; questionnaires; rural area; sign /symptom; urban area; young adult human (21-34)

DESCRIPTION (Adapted from the Applicant's Abstract): The inclusion of Premenstrual Dysphoric Disorder (PMDD) as a diagnostic category of DSM-IV has been hotly debated with controversy centering on the continued lack of empirical support for its existence. The proposed research seeks to provide evidence on whether PMDD exists and has diagnostic validity based on DSM-IV research criteria. Additional aims are to determine the prevalence of 1) PMDD co-occurring with other psychiatric disorders, 2) premenstrual exacerbations of other Axis 1 psychiatric disorders, and 3) past psychiatric disorders among women with and without a current diagnosis of PMDD. Two thousand six hundred women between the ages of 13 and 55 years will be selected by probability sampling and followed for two menstrual cycles. Half of the subjects will be drawn from the St. Louis MSA and half from the Chicago MSA. Urban and rural subsamples will be drawn from each of the two geographic areas. Subjects will be asked to complete daily symptom questionnaires and provide daily urine specimens for the period of study. The latter will be used to establish phase of cycle. Responses on the symptom questionnaire will be liked to phase of cycle so that symptom severity during the postmenstrual and premenstrual phases can be compared, as per the first DSM-IV research criteria. Symptom severity will be analyzed using the absolute severity method and the Trigg method of trend analysis. Other DSM-IV research criteria for PMDD will be addressed by following subjects for two cycles and via measures of 1) interference with functioning and 2) psychiatric diagnoses. Interference with functioning will be measured daily. Psychiatric interviews will be conducted in subjects' homes at the beginning of the study (to obtain current and lifetime diagnoses) and on a monthly basis thereafter (to assess premenstrual change in the symptoms of relevant psychiatric disorders). Rasch analysis will be used to confirm the definition of PMDD and to establish profiles of women with PMDD.

描述（改编自申请人的摘要）：包含 经前焦虑症 (PMDD) 作为 DSM-IV 的诊断类别 一直以来都存在着激烈的争论，争论的焦点是持续缺乏 其存在的实证支持。 拟议的研究旨在提供 基于 DSM-IV 的 PMDD 是否存在且具有诊断有效性的证据 研究标准。 其他目标是确定 1) 的患病率 PMDD 与其他精神疾病同时发生，2) 经前期 其他轴 1 精神疾病的恶化，以及 3) 过去的精神疾病 当前诊断为经前抑郁症（PMDD）和未诊断为经前抑郁症（PMDD）的女性中的疾病。 2600 名年龄在 13 岁至 55 岁之间的女性将 通过概率抽样选择并跟踪两个月经周期。 一半的受试者将从圣路易斯 MSA 抽取，一半从 芝加哥海事局。 城市和农村子样本将从两个样本中分别抽取 地理区域。 受试者将被要求完成日常症状 调查问卷并提供研究期间的每日尿液样本。 后者将用于建立循环阶段。 回应 症状调查问卷将适合周期的阶段，以便症状 可以比较经后和经前阶段的严重程度， 根据第一个 DSM-IV 研究标准。 症状严重程度将是 使用绝对严重性方法和趋势 Trigg 方法进行分析 分析。 其他关于 PMDD 的 DSM-IV 研究标准将由 跟踪受试者两个周期并通过以下措施 1) 干扰 功能和 2) 精神诊断。 干扰功能 将每天测量。 精神病学访谈将在 研究开始时受试者的家（以获得当前和 终生诊断）以及此后每月一次（以评估 相关精神疾病症状的经前变化）。 Rasch 分析将用于确认 PMDD 的定义并 建立患有经前抑郁症的女性档案。