PREVALENCE OF PREMENSTRUAL DYSPHORIC DISORDER

经前焦虑症的患病率

• 批准号: 2411211
• 负责人: SHIRLEY ANN HARTLAGE
• 金额: $ 51.89万
• 依托单位: RUSH UNIVERSITY MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-09-30 至 2000-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2411211
• 关键词: case history; clinical depression; clinical research; disease /disorder classification; female; human middle age (35-64); human subject; interview; major depression; menstrual cycle; mental disorder diagnosis; mental health epidemiology; premenstrual syndrome; questionnaires; rural area; sign /symptom; urban area; young adult human (21-34)

DESCRIPTION (Adapted from the Applicant's Abstract): The inclusion of Premenstrual Dysphoric Disorder (PMDD) as a diagnostic category of DSM-IV has been hotly debated with controversy centering on the continued lack of empirical support for its existence. The proposed research seeks to provide evidence on whether PMDD exists and has diagnostic validity based on DSM-IV research criteria. Additional aims are to determine the prevalence of 1) PMDD co-occurring with other psychiatric disorders, 2) premenstrual exacerbations of other Axis 1 psychiatric disorders, and 3) past psychiatric disorders among women with and without a current diagnosis of PMDD. Two thousand six hundred women between the ages of 13 and 55 years will be selected by probability sampling and followed for two menstrual cycles. Half of the subjects will be drawn from the St. Louis MSA and half from the Chicago MSA. Urban and rural subsamples will be drawn from each of the two geographic areas. Subjects will be asked to complete daily symptom questionnaires and provide daily urine specimens for the period of study. The latter will be used to establish phase of cycle. Responses on the symptom questionnaire will be liked to phase of cycle so that symptom severity during the postmenstrual and premenstrual phases can be compared, as per the first DSM-IV research criteria. Symptom severity will be analyzed using the absolute severity method and the Trigg method of trend analysis. Other DSM-IV research criteria for PMDD will be addressed by following subjects for two cycles and via measures of 1) interference with functioning and 2) psychiatric diagnoses. Interference with functioning will be measured daily. Psychiatric interviews will be conducted in subjects' homes at the beginning of the study (to obtain current and lifetime diagnoses) and on a monthly basis thereafter (to assess premenstrual change in the symptoms of relevant psychiatric disorders). Rasch analysis will be used to confirm the definition of PMDD and to establish profiles of women with PMDD.

描述（改编自申请人的摘要）：包含 经前烦躁不安（PMDD）作为DSM-IV的诊断类别 一直在争论，争论以继续缺乏 对其存在的经验支持。 拟议的研究旨在提供 有关PMDD是否存在并具有基于DSM-IV的诊断有效性的证据 研究标准。 其他目的是确定1的患病率） PMDD与其他精神疾病共同出现，2）经前 其他轴1精神疾病的加剧，3）过去的精神病学 有或没有当前对PMDD的妇女的疾病。 13至55岁之间的两千六百名妇女将是 通过概率采样选择，然后进行两个月经周期。 一半的受试者将从圣路易斯MSA中汲取 芝加哥MSA。 城市和农村子样本将从两者中的每一个中绘制 地理区域。 将要求受试者完成每日症状 问卷调查并为研究期提供每日尿液标本。 后者将用于建立周期阶段。 对 症状问卷将被认为是循环的阶段，以便症状 可以比较月经后和经前阶段的严重程度， 根据第一个DSM-IV研究标准。 症状严重程度将是 使用绝对严重性方法和TRIGG趋势方法分析 分析。 PMDD的其他DSM-IV研究标准将由 以下受试者进行两个循环，并通过1）干扰 功能和2）精神诊断。 干扰功能 将每天测量。 精神科访谈将在 研究开始时受试者的房屋（获得当前和 终生诊断）和以后每月的诊断（评估 相关精神疾病症状的经前改变）。 Rasch分析将用于确认PMDD的定义和 建立PMDD女性的个人资料。