Gordon Conference--Epigenetic Effects of Gene Expression

戈登会议--基因表达的表观遗传效应

• 批准号: 6361732
• 负责人: Eric U. SELKER
• 金额: $ 0.8万
• 依托单位: UNIVERSITY OF OREGON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-07-01 至 2002-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6361732
• 关键词: DNA methylation; chromatin; gene expression; meeting /conference /symposium

DESCRIPTION (provided by applicant) This proposal requests support for a Gordon Research Conference on Epigenetic Regulation of Gene Expression to be held at Holderness School, New Hampshire, August 12-17, 2001. Epigenetic regulation is mediated by the creation and maintenance of heritable, but potentially reversible, changes in chromatin structure and/or DNA methylation which alters gene expression without altering DNA sequence. Epigenetic effects have been discovered in many organisms and they comprise some of the most intriguing and actively investigated phenomena with relevance to both basic and applied science. For example, epigenetic silencing of transgenes poses problems for the long term, commercial use of transgenic plants engineered to express novel phenotypes and can complicate human gene therapy trials. Moreover, loss of epigenetically imprinted events on the chromosome are shown to cause many human cancer types. In addition, mutations in genes encoding DNA methyltransferase and a methyl-DNA binding protein lead to diseases in humans, namely ICF syndrome and Rett Syndrome, respectively. Advances have been made towards understanding the molecular mechanisms that underlie epigenetic silencing in the last few years and this will be a major focus of this conference. Invited speakers are leading researchers working on fungal, plant and animal models who will cover topics such as control and function of DNA methylation, chromatin-based gene silencing, post-transcriptional gene silencing, imprinting, X-inactivation, prions, epigenetics and disease, genome defense systems, paramutation and position effects. The Epigenetics Gordon Conference provides a unique opportunity for researchers working on related phenomena in different organisms to come together and exchange recent results and ideas. It is in a cross-disciplinary environment such as this that intellectual leaps occur and innovative ideas flourish.

描述（由申请人提供） 该提案要求支持戈登表观遗传学研究会议 监管基因表达在新罕布什尔州霍尔德尼斯学校举行的调节 2001年8月12日至17日。表观遗传调节是由创造和 维持可遗传但可能可逆的染色质变化 结构和/或DNA甲基化会改变基因表达而不改变的基因表达 DNA序列。 在许多生物体中发现了表观遗传效应， 它们构成了一些最有趣，最积极研究的现象 与基础科学和应用科学相关。 例如，表观遗传学 转基因的沉默会带来长期的问题，商业用途 经过设计用于表达新表型的转基因植物，可能会复杂化 人类基因治疗试验。 而且，表观遗传上印刷事件的丧失 染色体上显示出许多人类癌症类型。 此外， 编码DNA甲基转移酶和甲基-DNA结合的基因突变 蛋白质导致人类疾病，即ICF综合征和RETT综合征， 分别。 已经取得了进步来理解分子 在过去几年中表观遗传沉默的基础的机制 将是本次会议的重点。 受邀演讲者正在领导 研究真菌，动植物模型的研究人员将涵盖主题 例如DNA甲基化的对照和功能，基于染色质基因 沉默，转录后基因沉默，印迹，X灭活， 王室，表观遗传学和疾病，基因组防御系统，参数和参数 位置影响。 表观遗传学戈登会议提供了独特的 为研究不同现象的研究人员的机会 有机体聚集在一起，交换最新的结果和思想。 它在 诸如智力飞跃的跨学科环境和 创新思想蓬勃发展。