MICROELECTRODE ARRAYS FOR DEEP BRAIN STIMULATION AND REC

用于深部脑刺激和记录的微电极阵列

• 批准号: 6394378
• 负责人: Douglas Buchanan McCreery
• 金额: $ 37.25万
• 依托单位: HUNTINGTON MEDICAL RESEARCH INSTITUTES
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-09-30 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6394378
• 关键词: 6 hydroxydopamine; Parkinson's disease; action potentials; biomedical equipment development; cats; electronic recording system; electrostimulus; implant; injection /infusion; iridium; lenticular nucleus; medical implant science; methylphenyltetrahydropyridine; microdialysis; microelectrodes; nervous system disorder therapy; nonhuman therapy evaluation; silicon; stereotaxic techniques; subthalamus

This proposal is submitted in response to RFA NS-99-006; "Consortium on deep brain stimulation for the treatment of Parkinson's Disease." The proposal addresses the RFA's invitation to "develop microelectrodes that can simultaneously stimulate and record and perform microdialysis or infuse chemicals". We propose to develop arrays of 15 discrete activated iridium recording and/or stimulating microelectrodes suitable for very long-term implantation into the globus pallidus or the subthalamic nuclei. We will develop two array configurations. In Type 1, all of the microelectrodes will be usable for stimulating and recording of unitary neuronal action potentials. We will determine the optimal area of the exposed tips so that each electrodes will be capable of recording unit action potentials and also capable of stimulating nearby neurons in the globus pallidus and the subthalamic nucleus. In the Type 2 arrays, 9 of the microelectrodes will be designated for recording of unitary neuronal action potential, and will have geometric surface areas that are optimal for this function. Interspersed with the 9 recording electrodes will be 6 microelectrodes with geometric surface areas of 10,000 mum2, which will be reserved for stimulation. We will examine the relation between neuronal activity in the globus pallidus and subthalamic nuclei, and the parameters of electrical stimulation. These will include an investigation of long-lasting stimulation-induced depression of neuronal excitability, which may be especially germane to the treatment of Parkinson's disease. We will evaluate the arrays in cats in which a transient Parkinson's-like syndrome has been induced by MPTP, and we will attempt to identify a relation between the parameter of the electrical stimulation applied in the globus pallidus or subthalamic nuclei, the response of nearby neurons to the microstimulation, and changes in the cat's neurologic symptoms. We will attach multisite silicon substrate recording microelectrode arrays to some of the iridium shafts and these will be chronically implanted into the feline globus pallidus and subthalamic nuclei for up to 180 days.

该提案是根据RFA NS-99-006提交的； “关于帕金森氏病的深度脑刺激财团。” 该提案介绍了RFA的邀请：“开发可以同时刺激，记录和执行微透析或注入化学物质的微电极”。 我们建议开发15个离散激活的虹膜记录和/或刺激的微电极的阵列，适合于非常长期植入pallidus或丘脑下核。 我们将开发两个数组配置。 在类型1中，所有微电极都可用于刺激和记录单一神经元动作电位。 我们将确定暴露的尖端的最佳面积，以便每个电极能够记录单位动作电位，并且还能够刺激pallidus pallidus和丘脑下核的附近神经元。 在2型阵列中，将指定9个微电极以记录单一神经元动作电位，并具有最佳的几何表面区域，最适合该功能。散布在9个记录电极的散布将为6个微电极，几何表面积为10,000 MUM2，将保留用于刺激。我们将研究果胶球中神经元活性与丘脑下核之间的关系，以及电刺激的参数。 这些将包括对持续刺激引起的神经元兴奋性抑郁症的研究，这可能特别是对帕金森氏病的治疗。 我们将评估MPTP诱导的猫帕金森氏综合症的阵列，我们将尝试确定在plobus pallidus pallidus或丘脑下核中应用的电刺激参数之间的关系，附近神经元对微体刺激的反应以及猫的神经学症状的变化。我们将将多站点硅底物记录的微电极阵列连接到一些虹膜轴，并将其长期植入猫粒球粒和丘脑下核长达180天。