The Role of Stochasticity in the Evolution of Multicellularity

随机性在多细胞进化中的作用

• 批准号: 1781742
• 金额: --
• 依托单位: University of Cambridge
• 依托单位国家: 英国
• 项目类别: Studentship
• 财政年份: 2016
• 资助国家: 英国
• 起止时间: 2016 至 无数据
• 项目状态: 已结题
• 来源: https://gtr.ukri.org/projects?ref=studentship-1781742
• 关键词: Role; Stochasticity; Evolution; Multicellularity

One of the most fundamental issues in evolutionary biology, and more recently in biological physics, is the nature of transitions from unicellular organisms to multicellular ones. Many questions arise about the fitness advantages of increase in size and cell number, as well as cellular specialization, and these are often addressable from physical points of view. Of particular interest is the fidelity with which uni- and multicellular organisms sense and respond to environmental signals such as chemical concentrations and light intensity. This thesis project will investigate theoretically and possibly experimentally how the processes inherent in multicellular organisms deal with the intrinsic stochasticity in the world around them.

进化生物学中最根本的问题之一，以及最近在生物物理学中，是从单细胞生物到多细胞生物的过渡的性质。关于大小和细胞数量增加以及细胞专业化的适应性优势，出现了许多问题，并且通常可以从物理角度解决这些问题。特别令人感兴趣的是单细胞和多细胞生物感知并响应环境信号（例如化学浓度和光强度）的忠诚度。该论文项目将在理论上和实验上研究多细胞生物固有的过程如何处理周围世界上的内在随机性。

项目成果

Interkinetic nuclear migration in the zebra1sh retina as a diffusive process

斑马视网膜中运动核迁移作为扩散过程

• DOI: 10.1101/570606
• 发表时间: 2019
• 作者: Azizi A