GENETIC EPIDEMIOLOGY OF CHANGE IN CVD RISK FACTORS

CVD 危险因素变化的遗传流行病学

• 批准号: 6500887
• 负责人: DAVID MICHAEL HALLMAN
• 金额: $ 16.11万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-29 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6500887
• 关键词: age difference; cardiovascular disorder epidemiology; clinical research; disease /disorder proneness /risk; gene environment interaction; genetic polymorphism; genetic susceptibility; genotype; human subject; longitudinal human study

DESCRIPTION: While the onset of symptomatic cardiovascular disease (CVD) typically occurs in middle age or later, the development of the underlying pathology is clearly a long-term process, and early-state lesions having been identified at autopsy even in children. Understanding the course of CVD risk development from childhood into middle age will clearly be valuable both in understanding the pathology of CVD and in targeting preventive measure most effectively. Furthermore, while genetic factors are agreed to play a significant role in the development of CVD, most genes contributing to interindividual variation in CVD risk will have relatively small effects on risk for any given individual, even though their aggregate effects contribute significantly to CVD risk in the overall population. Relatively little is known about the effects of genetic variants on the course of CVD risk factor development in individuals over time. The Bogalusa Heart Study (BHS), which began in 1973 as a study of CVD risk factors in children but evolved to cover the development of CVD risk factors from childhood into early middle age, offers an unparalleled resource for investigating the genetic factors influencing within-individual changes over time in quantitative factors, such as serum lipid and blood pressure, related to CVD risk. In the proposed research, approximately 1500 individuals who were examined in the BHS on at least three separate occasions over a period of up to 20 years, and who consented to participate in studies of genetic factors influencing CVD risk, will have genotypes measured at selected loci either known or strongly suspected to affect interindividual variation in CVD risk. Longitudinal multilevel regression will be used to measure the effects of variation at these loci on quantitative CVD risk factor profiles within individuals and to determine whether some gene effects on CVD risk variation are age-dependent. The proposed research promises to extend our knowledge of the genetic factors affecting the course of CVD risk factor development over a substantial portion of an individual's lifetime.

描述：症状性心血管疾病（CVD）的发作 通常发生在中年或以后的基础发展 病理显然是一个长期过程，早期病变已经 即使在儿童中也可以在尸检中确定。了解CVD风险的过程 从童年到中年的发展显然将很有价值 了解CVD的病理和针对预防措施的大多数 有效地。此外，尽管同意遗传因素 在CVD的发展中重要作用，大多数基因有助于 CVD风险的个体差异将对 任何给定个人的风险，即使他们的综合效应有贡献 总体人口中的CVD风险很大。相对鲜为人知 关于遗传变异对CVD风险因素的影响 随着时间的流逝，个人的发展。 Bogalusa心脏研究（BHS），该研究 始于1973年，是针对儿童中CVD危险因素的研究，但已演变为覆盖 从童年到中年早期的CVD风险因素的发展， 提供无与伦比的资源来研究遗传因素 在定量因素中影响了个体内部变化，例如 作为血清脂质和血压，与CVD风险有关。 在拟议的研究中，大约有1500名在 在长达20年的时间内，BHS至少三个不同的场合， 谁同意参与影响CVD的遗传因素的研究 风险，将在已知或强烈的选定基因座中测得的基因型 怀疑会影响CVD风险的个体变化。纵向 多级回归将用于测量这些变化的影响 基因基因定量CVD危险因素概况以及个人内部和 确定某些基因对CVD风险差异的影响是否依赖于年龄。 拟议的研究有望扩大我们对遗传因素的了解 影响CVD风险因素的发展过程 一个人的一生。