GENETIC EPIDEMIOLOGY OF CHANGE IN CVD RISK FACTORS

CVD 危险因素变化的遗传流行病学

• 批准号: 6500887
• 负责人: DAVID MICHAEL HALLMAN
• 金额: $ 16.11万
• 依托单位: UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-29 至 2005-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6500887
• 关键词: age difference; cardiovascular disorder epidemiology; clinical research; disease /disorder proneness /risk; gene environment interaction; genetic polymorphism; genetic susceptibility; genotype; human subject; longitudinal human study

DESCRIPTION: While the onset of symptomatic cardiovascular disease (CVD) typically occurs in middle age or later, the development of the underlying pathology is clearly a long-term process, and early-state lesions having been identified at autopsy even in children. Understanding the course of CVD risk development from childhood into middle age will clearly be valuable both in understanding the pathology of CVD and in targeting preventive measure most effectively. Furthermore, while genetic factors are agreed to play a significant role in the development of CVD, most genes contributing to interindividual variation in CVD risk will have relatively small effects on risk for any given individual, even though their aggregate effects contribute significantly to CVD risk in the overall population. Relatively little is known about the effects of genetic variants on the course of CVD risk factor development in individuals over time. The Bogalusa Heart Study (BHS), which began in 1973 as a study of CVD risk factors in children but evolved to cover the development of CVD risk factors from childhood into early middle age, offers an unparalleled resource for investigating the genetic factors influencing within-individual changes over time in quantitative factors, such as serum lipid and blood pressure, related to CVD risk. In the proposed research, approximately 1500 individuals who were examined in the BHS on at least three separate occasions over a period of up to 20 years, and who consented to participate in studies of genetic factors influencing CVD risk, will have genotypes measured at selected loci either known or strongly suspected to affect interindividual variation in CVD risk. Longitudinal multilevel regression will be used to measure the effects of variation at these loci on quantitative CVD risk factor profiles within individuals and to determine whether some gene effects on CVD risk variation are age-dependent. The proposed research promises to extend our knowledge of the genetic factors affecting the course of CVD risk factor development over a substantial portion of an individual's lifetime.

描述：当有症状的心血管疾病 (CVD) 发作时 通常发生在中年或更晚，潜在的发展 病理学显然是一个长期的过程，早期状态的病变已被 即使在儿童中也能在尸检中发现。了解 CVD 风险的过程 从童年到中年的发展显然在以下方面都很有价值 了解CVD的病理并制定最有针对性的预防措施 有效地。此外，虽然遗传因素被认为发挥着重要作用 大多数基因在 CVD 的发展中发挥着重要作用 CVD风险的个体差异对健康的影响相对较小 任何特定个人的风险，即使其总体效应有助于 显着影响总体人群的 CVD 风险。知之甚少 关于遗传变异对CVD危险因素病程的影响 个人随着时间的推移而发展。博加卢萨心脏研究 (BHS) 始于 1973 年，最初是一项针对儿童 CVD 危险因素的研究，但后来发展到涵盖 CVD危险因素从童年到中年早期的发展， 为研究遗传因素提供了无与伦比的资源 随着时间的推移，影响个体内部的定量因素发生变化，例如 如血脂和血压，与CVD风险相关。 在拟议的研究中，约 1500 人接受了检查 BHS 在长达 20 年的时间内至少在三个不同的场合， 以及谁同意参加影响 CVD 的遗传因素的研究 风险，将在已知或强烈的选定位点测量基因型 怀疑影响CVD风险的个体差异。纵向 多级回归将用于衡量这些变化的影响 个体内定量 CVD 危险因素概况的位点 确定某些基因对 CVD 风险变异的影响是否与年龄有关。 拟议的研究有望扩展我们对遗传因素的了解 在很大程度上影响 CVD 危险因素发展的过程 一个人的一生。