INFLAMMATORY RESPONSE TO FETAL CARDIAC SURGERY

胎儿心脏手术的炎症反应

• 批准号: 6388763
• 负责人: SUNIL P MALHOTRA
• 金额: $ 1.17万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-04-01 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6388763
• 关键词: antiinflammatory agents; baboons; blood chemistry; congenital heart disorder; disease /disorder etiology; disease /disorder prevention /control; eicosanoid metabolism; embryo /fetus; embryo /fetus surgery; endothelin; heart /lung bypass; hemodynamics; inflammation; interleukin 6; nonhuman therapy evaluation; placenta disorders; postoperative complications; pregnancy; prostaglandins; thromboxanes; ultrasound blood flow measurement; vascular endothelium; vasoconstriction; vasoconstrictors

This research endeavor is aimed at understanding the effects of cardiac bypass on the fetus, with the hope that this knowledge will contribute to the development of safe corrective surgery for congenital heart disease in the human fetus. The advantages of early surgical intervention are obvious in defects that would require a much more challenging repair after birth. Prenatal repair would prevent the subsequent development of complex lesions during the fetal period. However, a detailed understanding of the effect of cardiac surgery and extracorporeal circulation on the fetus is required. The focus of this project is to identity the inflammatory mediators responsible for the fetal and placental pathophysiologic response to cardiac bypass using a fetal primate model. The role of cytokines, eicosanoids, and autocoids as candidate mediators of fetal and placental dysfunction will be examined. The effectiveness of attenuating this response with pharmacological antagonists of these putative mediators will also be explored.

这项研究的目的是了解心脏搭桥术对胎儿的影响，希望这些知识有助于开发人类胎儿先天性心脏病的安全矫正手术。对于出生后需要更具挑战性的修复的缺陷，早期手术干预的优势是显而易见的。产前修复可以防止胎儿时期复杂病变的发展。然而，需要详细了解心脏手术和体外循环对胎儿的影响。该项目的重点是使用胎儿灵长类动物模型来识别导致胎儿和胎盘对心脏搭桥的病理生理反应的炎症介质。将检查细胞因子、类二十烷酸和类胡萝卜素作为胎儿和胎盘功能障碍的候选介质的作用。还将探讨使用这些假定介质的药理学拮抗剂减弱这种反应的有效性。

项目成果

Cavopulmonary anastomosis induces pulmonary expression of the angiotensin II receptor family.

腔静脉肺吻合术诱导血管紧张素 II 受体家族的肺部表达。

• DOI: 10.1067/mtc.2002.119699
• 发表时间: 2002
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Malhotra,SunilP;Reddy,VMohan;Thelitz,Stephan;He,You-Ping;Hanley,FrankL;Suleman,Sam;Riemer,RKirk
• 通讯作者: Riemer,RKirk

Induced fibrillation is equally effective as crystalloid cardioplegia in the protection of fetal myocardial function.

诱导颤动在保护胎儿心肌功能方面与晶体停跳液同样有效。

• DOI: 10.1016/s0022-5223(02)73245-5
• 发表时间: 2003
• 期刊: The Journal of thoracic and cardiovascular surgery
• 作者: Malhotra,SunilP;Thelitz,Stephan;Riemer,RKirk;Reddy,VMohan;Suleman,Sam;Hanley,FrankL
• 通讯作者: Hanley,FrankL

Robotic-assisted endoscopic thoracic aortic anastomosis in juvenile lambs.

机器人辅助内窥镜幼年羔羊胸主动脉吻合术。

• DOI: 10.1532/hsf.879
• 发表时间: 2002
• 期刊: The heart surgery forum
• 作者: Malhotra,SunilP;Le,David;Thelitz,Stephan;Hanley,FrankL;Riemer,RKirk;Suleman,Sam;Reddy,VMohan
• 通讯作者: Reddy,VMohan

Fetal myocardial protection is markedly improved by reduced cardioplegic calcium content.

减少心脏停搏液钙含量可显着改善胎儿心肌保护作用。

• DOI: 10.1016/s0003-4975(03)00032-8
• 发表时间: 2003
• 期刊: The Annals of thoracic surgery
• 作者: Malhotra,SunilP;Thelitz,Stephan;Riemer,RKirk;Reddy,VMohan;Suleman,Sam;Hanley,FrankL
• 通讯作者: Hanley,FrankL