RETINA--THE CONTROL OF PHOTORECEPTOR CELL FATE

视网膜——感光细胞命运的控制

• 批准号: 6384804
• 负责人: ANDREW TOMLINSON
• 金额: $ 25.76万
• 依托单位: COLUMBIA UNIVERSITY HEALTH SCIENCES
• 依托单位国家: 美国
• 财政年份: 1999
• 资助国家: 美国
• 起止时间: 1999-05-01 至 2003-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6384804
• 关键词: Drosophilidae; alternatives to animals in research; biological signal transduction; cell differentiation; cellular polarity; color visions; compound eye; developmental genetics; developmental neurobiology; gene expression; genetic regulation; histogenesis; retina; visual photoreceptor

DESCRIPTION (Adapted from applicant's abstract): Patterning of the fly retina starts as the morphogenetic furrow sweeps through the eye imaginal disc. Successive waves of activation of the Ras pathway recruit the photoreceptors that form the ommatidia. However, the ommatidia are not all identical and later patterning events add at least two new features to the eye: one is to define the type of inner photoreceptors that are involved in detection of colored or polarized light. Another is to create chirality to the ommatidium that is essential for the correct projection pattern of the photoreceptors to the neural cartridges in the optic lobe. This new application offers to test the mechanisms underlying these two events and in particular the role of wnt's.

描述（改编自申请人的摘要）：视网膜的图案开始时，当形态发生的犁沟扫过眼睛的想象盘时。 RAS途径的连续激活募集了形成果皮的光感受器。但是，胶质膜并非全部相同，后来的图案事件至少为眼睛添加了两个新功能：一种是定义与检测有色或极化光的内部光感受器的类型。另一个是为羊皮创建手性，这对于光叶中神经墨盒的正确投影模式至关重要。该新应用程序旨在测试这两个事件的基础机制，尤其是WNT的作用。